| Description |
1 online resource (454 pages) |
| Contents |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface and Introduction; Acknowledgments; About the Editor; Part I Somatic Genome Variation in Animals and Humans; Chapter 1 Polyploidy in Animal Development and Disease; 1.1 Introduction; 1.2 Mechanisms Inducing Somatic Polyploidy; 1.2.1 Cell Fusion; 1.2.2 Acytokinetic Mitosis; 1.2.3 Endomitosis; 1.2.4 Endoreplication; 1.2.5 Gene Amplification; 1.2.6 Ploidy Reversal; 1.3 The Core Cell Cycle Machinery; 1.4 Genomic Organization of Polyploid Cells |
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1.5 Endoreplication: An Effective Tool for Post-Mitotic Growth and Tissue Regeneration1.6 Initiation of Endoreplication in Drosophila; 1.6.1 Endocycle Entry in Ovarian Follicle Cells; 1.6.2 Signaling Pathways Regulating Endocycle Entry in Follicle Cells; 1.6.3 Endocycle Entry in Other Tissues; 1.7 Mechanisms of Endocycle Oscillations in Drosophila; 1.7.1 An Autonomous Oscillator Drives Endocycling in the Salivary Gland; 1.7.2 Alternative Modes of Endoreplication; 1.8 Gene Amplification in Drosophila Follicle Cells; 1.8.1 Molecular Mechanism of Gene Amplification |
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1.8.2 The Endocycle-to-Amplification Switch1.9 Endocycle Entry in the Trophoblast Lineage; 1.10 Mechanisms of Endocycle Oscillations in Trophoblast Giant Cells; 1.11 Cardiomyocytes; 1.11.1 Upstream Control of Cardiomyocyte Polyploidization; 1.11.2 Mechanisms of Cardiomyocyte Polyploidization; 1.11.3 Polyploidization as a Response to Tissue Damage; 1.12 Hepatocytes; 1.12.1 Mechanisms of Hepatocyte Polyploidization; 1.12.2 The Ploidy Conveyor Model; 1.12.3 Liver Regeneration; 1.13 Megakaryocytes; 1.13.1 Mechanisms of MKC Polyploidization; 1.14 Concluding Remarks; Acknowledgments; References |
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Chapter 2 Large-Scale Programmed Genome Rearrangements in Vertebrates2.1 Introduction; 2.1 Hagfish; 2.2.1 Content of Eliminated DNA; 2.2.2 Results and Mechanisms of Deletion; 2.3 Sea Lamprey; 2.3.1 Content of Eliminated DNA; 2.3.2 Results and Mechanisms of Deletion; 2.4 Zebra Finch; 2.4.1 Mechanisms of Deletion; 2.4.2 Content of Eliminated DNA; 2.5 Emerging Themes and Directions; 2.5.1 The Biological Function of PGR; 2.5.2 Mechanisms of Deletion; 2.5.3 Other Vertebrates?; References; Chapter 3 Chromosome Instability in Stem Cells; 3.1 Introduction; 3.2 Pluripotent Stem Cells |
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3.2.1 Primate Embryonic Stem Cells3.2.2 Mouse Embryonic Stem Cells; 3.2.3 Parthenogenetic Embryonic Stem Cells; 3.2.4 Induced Pluripotent Stem Cells; 3.3 Somatic Stem Cells; 3.3.1 Mesenchymal Stem Cells; 3.3.2 Neural Stem Cells; 3.4 Mechanisms of Chromosomal Instability; 3.4.1 Dysfunction in the Spindle Assembly Checkpoints; 3.4.2 Defects of Microtubule Attachment to the Kinetochore; 3.4.3 Supernumerary Centrosomes; 3.4.4 Sister Chromatids Cohesion; 3.5 Mechanisms of Chromosomal Instability in Stem Cells; References; Part II Somatic Genome Variation in Plants |
| Notes |
Chapter 4 Mechanisms of Induced Inheritable Genome Variation in Flax |
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Print version record |
| Subject |
Genetic Variation
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| Form |
Electronic book
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| ISBN |
9781118647127 |
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1118647122 |
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