Limit search to available items
Book Cover
Author Lavielle, Marc.

Title Mixed Effects Models for the Population Approach : Models, Tasks, Methods and Tools
Published London : CRC Press, 2014
Online access available from:
ProQuest Ebook Central Subscription    View Resource Record  
Safari O'Reilly books online    View Resource Record  


Description 1 online resource (380 pages)
Series Chapman & Hall/CRC Biostatistics series
Chapman & Hall/CRC biostatistics series.
Contents Front Cover -- Contents -- Preface -- Part I: Introduction and Preliminary Concepts -- Chapter 1: Overview -- Chapter 2: Mixed Effects Models vs Hierarchical Models -- Chapter 3: What is a Model? A Joint Probability Distribution! -- Part II: Defining Models -- Chapter 4: Modeling the Observations -- Chapter 5: Modeling the Individual Parameters -- Chapter 6: Extensions -- Part III: Using Models -- Chapter 7: Tasks and Methods -- Chapter 8: Examples -- Chapter 9: Algorithms -- Part IV: Appendices -- A: The Individual Approach -- B: Some Useful Results -- C: Introduction to Pharmacokinetics Modeling -- D: Tools -- Bibliography -- Glossary -- Back Cover
Summary Wide-Ranging Coverage of Parametric Modeling in Linear and Nonlinear Mixed Effects Models Mixed Effects Models for the Population Approach: Models, Tasks, Methods and Tools presents a rigorous framework for describing, implementing, and using mixed effects models. With these models, readers can perform parameter estimation and modeling across a whole population of individuals at the same time. Easy-to-Use Techniques and Tools for Real-World Data Modeling The book first shows how the framework allows model representation for different data types, including continuous, categorical, count, and time-to-event data. This leads to the use of generic methods, such as the stochastic approximation of the EM algorithm (SAEM), for modeling these diverse data types. The book also covers other essential methods, including Markov chain Monte Carlo (MCMC) and importance sampling techniques. The author uses publicly available software tools to illustrate modeling tasks. Methods are implemented in Monolix, and models are visually explored using Mlxplore and simulated using Simulx. Careful Balance of Mathematical Representation and Practical Implementation This book takes readers through the whole modeling process, from defining/creating a parametric model to performing tasks on the model using various mathematical methods. Statisticians and mathematicians will appreciate the rigorous representation of the models and theoretical properties of the methods while modelers will welcome the practical capabilities of the tools. The book is also useful for training and teaching in any field where population modeling occurs
Notes Publisher supplied metadata and other sources
Subject Biometry.
Form Electronic book
ISBN 1482226510