| Description |
1 online resource (575 pages) : illustrations (some color) |
| Contents |
Front cover; Preface; Contents; Contributors; Part I Mechanisms of Damage Recognition: Theoretical Considerations; Dynamics of DNA Damage Recognition; 1. INTRODUCTION; 2. ROLE OF DNA FLEXIBILITY IN SEQUENCE-DEPENDENT ACTIVITY OF UDG; 3. OPENING AND BENDING DYNAMICS OF G U MISMATCHES IN DNA; 4. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; In Search of Damaged Bases; 1. INTRODUCTION; 2. MECHANISM FOR AN INCREASED RATE OF TARGET SITE LOCATION; 3. IN VITRO EVIDENCE FOR PROCESSIVE NICKING ACTIVITY OF DNA GLYCOSYLASES 3.1. Bacteriophage T4 Pyrimidine Dimer Glycosylase; 3.2. Other DNA Glycosylases |
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4. DISCOVERY AND SIGNIFICANCE OF IN VIVO PROCESSIVE NICKING ACTIVITY BY T4-PDG 4.1. In Vivo Evidence for Processive Incision and Repair of UV Irradiated DNAs4.2. Biological Significance of the Processive Incision Activity of T4-pdg; 5. DNA BENDING AS A POTENTIAL PREREQUISITE FOR NUCLEOTIDE FLIPPING; 6. MECHANISMS OF NUCLEOTIDE FLIPPING 6.1. Flipping of a Single Nucleotide; 6.2. Double Flipping; 7. SPECIFICITY OF GLYCOSYLASE BINDING SITES AND CATALYTIC ACTIVITIES; REFERENCES; Increased Specificity and Efficiency of Base Excision Repair Through Complex Formation; 1. INTRODUCTION |
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2. DNA LESION RECOGNITION AND REMOVAL2.1. Glycosylase Stimulation by AP Endonuclease; 2.2. Post-Translational Modification of DNA Glycosylases; Table 2; 2.3. Bi-functional Glycosylases; 3. STRAND INCISION; 4. GAP FILLING AND RELIGATION; 4.1. Protein Interactions with pol-b in Short-Patch BER; 4.2. Protein Interactions with pol-b in Long-Patch BER; 4.3. Post-Translational Modifications; 5. XRCC1 COORDINATION; 5.1. DNA Damage Recognition; 5.2. XRCC1 Scaffold Coordination; 6. LONG-PATCH REPAIR; 6.1. Protein Interactions; 6.2. Post-Translational Modifications; 7. EMERGING SUBPATHWAYS |
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8. CONCLUSIONSACKNOWLEDGMENTS; REFERENCES; Part II UV Damage and Other Bulky DNA-Adducts; Structure and Properties of DNA Photoproducts; 1. INTRODUCTION; 1.1. DNA Photochemistry; 1.2. Primary Photoproducts; 2. CYCLOBUTANE PYRIMIDINE DIMERS; 2.1. Secondary Reactions of CPDs; 2.2. Tautomerization; 2.3. Deamination of C-Containing CPDs; 2.4. Tertiary Structure of Cis-Syn Cyclobutane Dimer-Containing DNA; 2.5. Base Pairing and Thermodynamic Properties; 3. OTHER DIMER-RELATED PRODUCTS 3.1. Dimers with a Cleaved Intradimer Phosphodiester Backbone; 3.2. Non-Adjacent Dimers; 3.3. Trans-Syn Dimers |
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4. (6-4) PRODUCTS4.1. Tertiary Structure of (6-4)-Containing DNA; 4.2. Base Pairing and Thermodynamic Properties of (6-4)-Containing DNA; 5. DEWAR PHOTOPRODUCT; 5.1. Tertiary Structure of Dewar-Containing DNA; 5.2. Base Pairing and Thermodynamic Stability of Dewar-Containing Duplexes; 5.3. Thio Analogs of (6-4) and Dewar Products; 6. SPORE PHOTOPRODUCT; 7. TA+ PRODUCT; 7.1. AA+ and Porschke Photoproducts; 8. CONCLUSIONS; REFERENCES; Damage Recognition by DNA Photolyases; 1. OVERVIEW OF PHOTOLYASES; 2. THE NATURE OF THE SUBSTRATES |
| Summary |
Analytical Microsystems: A Bird's Eye View; C.S. Effenhauser Microfluidics: Some Basics; S.C. Jacobson and C.T. Culbertson Microfabrication and Integration; J.G.E. Gardeniers and A. van den Berg New Tools: Scalar Imaging, Velocimetry, and Simulation; E.F. Hasselbrink, Jr. and S. Madhavan-Reese Transport Modes: Realizations and Practical Considerations; S.R. Wallenborg, P. Andersson, and G. Thorsén Pressure-Driven Separation Methods on a Chip; G. Desmet, E. Chmela, and R. Tijssen Transverse Transport in Microsystems: Theory and Applications; P. Yager, C. Cabrera, and A. Kamholz El |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Separation (Technology)
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Microelectromechanical systems.
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Micro-Electrical-Mechanical Systems
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Microelectromechanical systems
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Separation (Technology)
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| Form |
Electronic book
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| Author |
Kutter, Jorg P
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Fintschenko, Yolanda
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| LC no. |
2005012833 |
| ISBN |
9781420027938 |
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142002793X |
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9780824725303 |
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0824725301 |
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