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E-book

Title Neuro-Behçet's disease : pathogenesis, clinical aspects, treatment / Erdem Tüzün, Murat Kürtüncü, editors
Edition 1st ed
Published Cham : Springer, 2021

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Description 1 online resource
Contents Intro -- Preface -- Contents -- Neuro-Behçet's Disease: Epidemiology and Genetics -- Introduction -- Epidemiology -- Prevalence of Neuro-Behçet's Disease -- Age -- Gender -- Genetic Factors -- Familial Aggregation -- HLA-B51 -- Other MHC Class I Genes -- Non-MHC Complex Genes -- Genome-Wide Association Studies -- Il-10 -- IL23R-IL12RB2 -- IL12A -- ERAP1 -- STAT4 -- TNFAIP3 -- CCR1-CCR3 -- KLR -- GIMAP -- FUT2 -- CPLX-1 -- Other Polymorphism Studies -- Rare Non-synonymous Variants -- Epigenetic Studies -- Conclusion -- References -- Immunology of Neuro-Behcet's Disease (NBD)
Immune Response in the CSF -- Cellularity of CSF -- Immune Mediators as Indications of Activity in CSF -- Oligoclonal Bands (OCB) -- Other Markers in the CSF -- Cytokines -- Candidate Antigens of Possible Autoimmune Response in NBD -- Heat Shock Protein (HSP) and Related Responses -- Neuronal and Other Proteins -- Cellular Immune Response in NBD -- Other Mechanisms in BD -- Inflammation, Coagulation, and Fibrinolytic Pathway Abnormalities -- Severity and Gender -- Conclusions -- References -- Autoantibodies in Neuro-Behçet Disease -- References -- Animal Models of Behçet's Disease -- Introduction
Infection-Induced Models -- Herpes Simplex Virus-Induced Model -- Streptococcal Infection Model -- Genetic Models -- Immunological Models -- Heat Shock Protein Model -- Anti-neuronal Antibody Model -- Tropomyosin Model -- Retinal S-Antigen Model -- Environmental Models -- Therapeutic Studies of BD Animal Models -- Conclusion -- References -- Pathology -- Parenchymal NBD -- Histological Findings -- Non-parenchymal NBD -- Peripheral Nervous System Involvement -- References -- Behçet's Disease: Clinical Features -- Introduction -- Clinical Features -- Mucocutaneous Involvement
Recurrent Aphthous Ulcers -- Genital Ulcers -- Cutaneous Lesions -- Pathergy Reaction -- Eye Involvement -- Musculoskeletal Disease -- Vascular Involvement -- Gastrointestinal Involvement -- Other Clinical Findings -- References -- Neuro-Behçet Syndrome: Differential Diagnosis -- Differentiation of p-NBS from Other Mimickers by MRI Patterns -- Differentiation of p-NBS from Other Mimickers by Laboratory Findings -- Differentiation of p-NBS from Other Mimickers by Pathological Findings -- References -- Neuro-Behçet Syndrome: Clinical Features -- Parenchymal NBS -- Neurovascular Involvement
Cerebral Venous Sinus Thrombosis (CVST) -- Arterial Occlusion and Aneurysm Formation -- Primary Neurological Conditions Other than p-NBS and Neurovascular Involvement -- Regarding Clinical Features, When Should We Suspect NBS? -- References -- The Cerebrospinal Fluid Presentations of Neuro-Behçet Disease -- CSF Cells -- CSF Protein -- CSF Glucose -- Oligoclonal Bands -- Interleukin-6 -- Other CSF Studies -- References -- Imaging of Neuro-Behçet's Disease -- Introduction -- Neuroimaging Tools in NBD
Summary This contributed volume provides a complete overview of Neuro-Behcets disease (NBD), one of the most serious manifestations of Behcets disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields
Notes Includes index
Print version record
Subject Behçet's disease.
Nervous system -- Diseases.
Behcet Syndrome
Nervous System Diseases
Behçet's disease
Nervous system -- Diseases
Genre/Form Electronic books
Form Electronic book
Author Tüzün, Erdem
Kürtüncü, Murat
ISBN 9783030552732
303055273X