| Description |
1 online resource (ix, 424 pages) : illustrations |
| Series |
Subcellular biochemistry ; volume 102 |
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Sub-cellular biochemistry ; v. 102.
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| Contents |
Intro -- Preface -- Contents -- About the Editors -- Chapter 1: Introduction: Progression of the Science of Ageing -- Introduction -- References -- Chapter 2: Chromatin Structure from Development to Ageing -- Introduction -- Nuclear Architecture -- The Nuclear Envelope -- Nuclear Lamina -- Chromosome Territories -- Chromatin 3D Organization and Dynamics -- Compartments -- Topologically Associated Domains (TADs) -- Lamina-Associated Domains (LADs) -- Chromatin Restructuring During Development -- DNA Methylation -- Histone Variants -- Histone Modifications -- Nuclear Remodeling in Development |
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Lamins Regulate Nuclear Structure and Chromatin Organization During Development -- Programmed Cellular Senescence -- Chromatin Remodeling in Ageing -- Persistent Cellular Senescence -- Changes in Chromatin Structure and Histone Variants in Cellular Senescence -- DNA Methylation -- Histone Variants and Modifications -- Nuclear and 3D Genome Remodeling in Ageing -- The Role of Lamins in Regulating Chromatin Organization During Ageing -- Concluding Remarks -- References -- Chapter 3: The Nuclear Envelope in Ageing and Progeria -- Introduction |
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The Nuclear Lamina in Ageing and Premature Ageing Syndromes -- Nuclear Pore Complex Turnover and Decline in Ageing -- The Implication of Nucleocytoplasmic Transport in Neurodegenerative Disease -- RNA-Binding Proteins and Neurodegenerative Diseases -- Peptide Repeat Toxicity and NPC Function -- Additional Implications of NCT in Neurodegenerative Diseases -- Concluding Remarks -- References -- Chapter 4: Mitochondrial DNA Mutations and Ageing -- Introduction -- Mitochondrial Structure and Function -- Oxidative Phosphorylation -- Mitochondrial Genetics -- Mitochondrial DNA Mutations in Ageing |
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MtDNA Deletions -- MtDNA Point Mutations -- Mouse Models of Mitochondrial Alterations with Ageing -- Mitochondrial Function and Stem Cell Ageing -- MtDNA Mutations and Stem Cell Ageing -- Mitochondrial Regulation of the Ageing Immune System -- Targeting Mitochondria in Ageing -- Concluding Remarks -- References -- 5: The Proteasome and Ageing -- Introduction -- The Proteasome: A Brief Overview -- Cellular Senescence and the Proteasome -- Muscle Ageing and the Proteasome -- Skin Ageing and the Proteasome -- Brain Ageing and the Proteasome -- Proteasome and Age-Related Neurodegenerative Diseases |
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Proteasome and Longevity -- Other Components of the Ubiquitin-Proteasome Pathway Implicated in Ageing -- Activating the Proteasome to Decelerate the Ageing Process -- Conclusion and Future Directions -- References -- 6: Gap Junctions and Ageing -- Introduction -- Gap Junctions and the Connexin Family -- Regulation of Gap Junctions at the Molecular Level -- Gene Structure and Transcription -- Translation -- Trafficking -- Posttranslational Modification of Connexins -- Heart -- Brain -- The Ocular System -- Bone -- Other Tissues -- Concluding Remarks -- References |
| Summary |
This, our third book on the Biochemistry and Cell Biology of Ageing in the Subcellular Biochemistry series, expands on the content of Part I, by covering additional biomedical topics. The 16 chapters included here, contributed by international knowledgeable scientists, review these further interesting topics at an advanced level. Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell, Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed January 12, 2023) |
| Subject |
Aging -- Molecular aspects.
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Cells -- Aging.
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Clinical biochemistry.
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Aging -- Molecular aspects
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Cells -- Aging
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Clinical biochemistry
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| Form |
Electronic book
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| Author |
Harris, J. Robin (James Robin), editor.
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Korolchuk, Viktor I., editor.
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| ISBN |
9783031214103 |
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3031214102 |
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