Description |
xviii, 306 pages : illustrations ; 24 cm |
Series |
Computational molecular biology |
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Computational molecular biology.
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Contents |
1. Introduction -- 1.1. The Future Is So Bright ... -- 1.2. Functional Genomics -- 1.3. Missing the Forest for the Dendrograms -- 1.4. Functional Genomics, Not Genetics -- 1.5. Basic Biology -- 2. Experimental Design -- 2.1. The Safe Conception of a Functional Genomic Experiment -- 2.2. Gene-Clustering Dogma -- 3. Microarray Measurements to Analyses -- 3.1. Generic Features of Microarray Technologies -- 3.2. Replicate Experiments, Reproducibility, and Noise -- 3.3. Prototypical Objectives and Questions -- 3.4. Preprocessing: Filters and Normalization -- 3.5. Background on Fold -- 3.6. Dissimilarity and Similarity Measures -- 4. Genomic Data-Mining Techniques -- 4.1. Introduction -- 4.2. What Can Be Clustered in Functional Genomics? -- 4.3. What Does it Mean to Cluster? -- 4.4. Hierarchy of Bioinformatics Algorithms -- 4.5. Data Reduction and Filtering -- 4.6. Self-Organizing Maps -- 4.7. Finding Genes That Split Sets -- 4.8. Phylogenetic-Type Trees -- 4.9. Relevance Networks -- 4.10. Other Methods -- 4.11. Which Technique Should I Use? -- 4.12. Determining the Significance of Findings -- 4.13. Genetic Networks -- 5. Bio-Ontologies, Data Models, Nomenclature -- 5.1. Ontologies -- 5.2. Expressivity versus Computability -- 5.3. Ontology versus Data Model versus Nomenclature -- 5.4. Data Model Introduction -- 5.5. Nomenclature -- 5.6. Postanalysis Challenges -- 6. From Functional Genomics to Clinical Relevance -- 6.1. Electronic Medical Records -- 6.2. Standardized Vocabularies for Clinical Phenotypes -- 6.3. Privacy of Clinical Data -- 6.4. Costs of Clinical Data Acquisition -- 7. The Near Future -- 7.1. New Methods for Gene Expression Profiling -- 7.2. Respecting the Older Generation -- 7.3. Selecting Software -- 7.4. Investing in the Future of the Genomic Enterprise |
Notes |
"Bradford book." |
Bibliography |
Includes bibliographical references and index |
Subject |
Gene expression -- Analysis -- Automation.
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DNA.
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Bioinformatics.
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DNA microarrays.
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Genomics -- Automation.
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Author |
Kho, Alvin
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Butte, Atul J.
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LC no. |
2002022663 |
ISBN |
0262612100 paperback |
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026211271X : |
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