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Author Klingensmith, William C., author.

Title The mathematics and biology of the biodistribution of radiopharmaceuticals -- a clinical perspective / William C. Klingensmith III
Published Cham : Springer, 2016


Description 1 online resource (xv, 274 pages) : illustrations (some color)
Contents Part I: Introduction: General Nuclear Medicine Concepts -- Quantitative vs Visual Interpretation of Images. Part II: Mathematics of the Biodistribution of Radiopharmaceuticals: Mathematics of the Biodistribution of Radiopharmaceuticals -- Evaluation of Clearance -- Mean Transit Time -- Central Volume Principle -- Blood Flow -- First Circulation Time-Activity Curves -- Parenchymal Transit Times -- Convolution Analysis -- Quantitation of Function -- Relative -- Quantitation of Function -- Absolute -- Other Quantitative Techniques. Part III: Overview of Part 3 -- Cardiovascular System -- Central Nervous System -- Endocrine System -- Gastrointestinal System -- Genitourinary System -- Infection Imaging -- Pulmonary System -- Skeletal System -- Tumor Imaging. Appendix A -- Nuclear Medicine Studies Covered in Part 3 Appendix B -- Radiopharmaceuticals and Associated Studies Appendix C -- Tables of Clearance Mechanisms
Summary This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective - from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e.g., renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed April 14, 2016)
Subject Radiopharmaceuticals -- Mathematical models
Medical physics.
Nuclear medicine.
MEDICAL -- Pharmacology.
Form Electronic book
ISBN 9783319267043