1 CD-ROM (PDF file (201 pages, illustrations)) ; 12 cm
4 3/4 in
Summary
This project examined the impact of pegylation on secondary structure of insulin during tablet making process and assessed the metabolism in in-vitro and in-vivo model. It was found that pegylation per se does not affect the secondary structure of insulin. The tablet making process did not have any impact on the pegylated insulin structure. In the in vitro model and in vivo model, pegylated lysine and free peg molecule were found to be the metabolites specific to pegylated insulin
Notes
Submitted to the School of Life and Environmental Sciences in the Faculty of Science, Engineering and Built Environment, Deakin University
