| Description |
1 online resource |
| Series |
Advances in experimental medicine and biology, 0065-2598 ; v. 754 |
|
Advances in experimental medicine and biology ; v. 754.
|
| Contents |
Part 1. Epigenetic Marks and Mechanisms -- DNA Methyltransferases, DNA Damage Repair, and Cancer / Bilian Jin and Keith D. Robertson -- DNA Hypomethylation and Hemimethylation in Cancer / Melanie Ehrlich and Michelle Lacey -- Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancer / Shannon R. Morey Kinney and Sriharsa Pradhan -- Altered Histone Modifications in Cancer / Moray J. Campbell and Bryan M. Turner -- Nucleosome Occupancy and Gene Regulation During Tumorigenesis / C.V. Andreu-Vieyra and G. Liang |
|
Part 2. The Impact of Epigenetic Alterations on Cancer Biology -- Epigenetic Regulation of miRNAs in Cancer / Muller Fabbri, Federica Calore, Alessio Paone, Roberta Galli and George A. Calin -- DNA Hypomethylation and Activation of Germline-Specific Genes in Cancer / Charles De Smet and Axelle Loriot -- APC and DNA Demethylation in Cell Fate Specification and Intestinal Cancer / Angela Andersen and David A. Jones -- Epigenetic Changes During Cell Transformation / Bernard W. Futscher -- Epigenetic Reprogramming of Mesenchymal Stem Cells / Yu-Wei Leu, Tim H.-M. Huang and Shu-Huei Hsiao |
|
Part 3. Clinical Implications and Analysis Methods -- Environmental Toxicants, Epigenetics, and Cancer / Igor P. Pogribny and Ivan Rusyn -- Blood-Derived DNA Methylation Markers of Cancer Risk / Carmen Marsit and Brock Christensen -- Epigenetic Therapies in MDS and AML / Elizabeth A. Griffiths and Steven D. Gore -- Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance / Curt Balch and Kenneth P. Nephew -- Methods for Cancer Epigenome Analysis / Raman P. Nagarajan, Shaun D. Fouse, Robert J.A. Bell and Joseph F. Costello |
| Summary |
The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means "above" genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book |
| Analysis |
Medicine |
|
Oncology |
|
Human genetics |
|
Biomedicine |
|
Cancer Research |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| In |
Springer eBooks |
| Subject |
Carcinogenesis -- Molecular aspects.
|
|
Epigenetics.
|
|
Cell Transformation, Neoplastic
|
|
Epigenesis, Genetic
|
|
Neoplasms -- genetics
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
MEDICAL -- Oncology.
|
|
Carcinogenesis -- Molecular aspects
|
|
Epigenetics
|
| Form |
Electronic book
|
| Author |
Karpf, Adam R., 1969-
|
| LC no. |
2012945005 |
| ISBN |
9781441999672 |
|
1441999671 |
|
1441999663 |
|
9781441999665 |
|
1283621894 |
|
9781283621892 |
|
9786613934345 |
|
6613934348 |
|
