Title Cerebral ischemic reperfusion injuries (CIRI) : bench research and clinical implications / Weijian Jiang, Wengui Yu, Yan Qu, Zhongsong Shi, Benyan Luo, John H. Zhang, editors

Published Cham, Switzerland : Springer, 2018

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Description 1 online resource (xvii, 259 pages) : illustrations (some color) Series Springer series in translational stroke research, 2363-958X Springer series in translational stroke research, 2363-958X Contents Intro; Preface; Introduction; Recanalization-Related Injury; Safety and Efficacy of Late Recanalization; The Application of New Imaging Technique and Strategies; The Characteristics of Posterior Circulation Stroke; The Immune Regulation and Stroke; The Cerebral Venous System and Stroke; Contents; About the Editors; Chapter 1: Gelatinase-ƯMediated Impairment of Microvascular Beds inCerebral Ischemia and Reperfusion Injury; 1 Introduction; 2 Microvascular Beds andtheExtracellular Matrix (ECM); 3 Gelatinases Mediate Impairment of Microvascular Beds inCIRI 4 Activation of Gelatinases and Extravasation oftPA intoBrain Parenchyma inCIRI-Induced Microvascular Bed Damage5 Early Inhibition of Gelatinases May Escalate Neuroprotection and Extend thetPA Therapeutic Window; References; Chapter 2: Characters of Ischemic Stroke and Recanalization Arteries; 1 Introduction; 2 Characters oftheIschemic Stroke; 2.1 Epidemiology and Risk Factors of Ischemic Stroke; 2.2 The Imaging and Diagnosis of Ischemic Stroke; 2.3 The Pathophysiology of Ischemic Stroke; 2.3.1 Excitotoxicity; 2.3.2 Inflammatory Response; 2.3.3 Apoptosis; 2.3.4 Autophagy 2.3.5 Pyroptosis3 Artery Recanalization of Ischemic Stroke; 3.1 Intravenous Thrombolytic and Antiplatelet Therapy Treatment; 3.2 Endovascular Treatment forAcute Ischemic Stroke; 3.3 Antioxidant and Other Treatment; 4 Reperfusion Injury After Artery Recanalization; 5 Conclusion; References; Chapter 3: Cerebral Ischemic Reperfusion Injury (CIRI) Cases; 1 Case Description; 2 Discussion; References; Chapter 4: CIRI After Early Recanalization; 1 Hemorrhage Transformation (HT); 1.1 Mechanisms; 1.1.1 Oxidative Stress; 1.1.2 Neurovascular Unit Injury; 1.2 Predictive Imaging Markers 1.2.1 Brain-Blood Barrier Permeability1.2.2 Postischemic Hyperperfusion; 2 Infarct Growth; 2.1 Mechanisms; 2.1.1 Apoptosis; 2.1.2 Neutrophil Infiltration and Immune Inflammation; 2.2 Predictive Imaging Markers; 2.2.1 No-Reflow Phenomenon; 2.2.2 Cerebral Neutrophil Recruitment; 2.2.3 Vascular Inflammation; 2.2.4 Postischemic Hyperperfusion; 3 Brain Edema; 3.1 Mechanisms and Edema Types; 3.1.1 Brain-Blood Barrier Damage and Vasogenic Edema; 3.1.2 Postischemic Hyperperfusion and Cytotoxic Edema; 4 Treatments; 4.1 Ischemic Conditioning Therapy; 4.1.1 Ischemic Preconditioning Therapy 4.1.2 Ischemic Postconditioning Therapy4.2 Immunosuppressive Agents; 4.3 Hypothermia Treatment; 5 Conclusion; References; Chapter 5: Programmed Cell Death inCIRI; 1 Introduction; 2 Apoptotic Cell Death inCIRI; 2.1 Molecular Biology Mechanism of Apoptosis AfterIschemic Stroke; 2.1.1 Molecules Related toApoptosis of Neurons; Caspase Family; B-Cell Leukemia/Lymphoma 2 (Bcl-2) Family; Tumor Necrosis Factor Receptor (TNFR) Superfamily; Other Molecules; 2.2 Pathways Related toApoptosis of CIRI; 2.2.1 Intrinsic Pathway; 2.2.2 Extrinsic Pathway; 2.3 Significance of Apoptosis inCIRI Summary This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi'an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA Notes Online resource; title from PDF title page (SpringerLink, viewed July 10, 2018) Subject Cerebral ischemia. Reperfusion injury. Brain Ischemia Reperfusion Injury HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Cerebral ischemia Reperfusion injury Form Electronic book Author Jiang, Weijian, editor Yu, Wengui, editor Qu, Yan, editor Shi, Zhongsong, editor Luo, Benyan, editor Zhang, J. H. (John H.), editor. ISBN 9783319901947 331990194X

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