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Book Cover
E-book
Author Jena, Bhanu P.

Title Cellular nanomachines : from discovery to structure-function and therapeutic applications / Bhanu P. Jena
Published Cham : Springer, 2020

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Description 1 online resource
Contents Intro -- Foreword -- Preface -- Introduction -- Contents -- Chapter 1: Porosome: Cells Secretory Nanomachine -- Introduction -- Porosome Discovery -- Porosome Structure and Dynamics -- Porosome: Isolation and Composition -- Porosome: Functional Reconstitution in Lipid Membrane and Live Cells -- Establishment of the t-/v-SNARE Rosette or Ring Complex at the Porosome Base -- Vesicle Volume Regulates Porosome-Mediated Fractional Content Release -- Porosome in Health and Disease -- References -- Chapter 2: Ubiquitin-Proteasome Machinery: Cells Garbage Disposal -- Discovery
Proteasome Structure-Function -- Disease and Treatments Targeting the Proteasome -- References -- Chapter 3: Chaperonin: Protein Folding Machinery in Cells -- Discovery -- Structure-Function -- Disease Resulting from Alterations in Chaperonin -- References -- Chapter 4: ATP Synthase: Energy Generating Machinery in Cells -- Discovery and Structure-Function -- Disease Resulting from Altered ATP Synthase -- References -- Chapter 5: Ribosome: Cells Protein Synthetic Machinery -- Discovery -- Structure-Function -- Ribosome in Health and Disease -- References
Chapter 6: Nuclear Pore: A Bidirectional Transport Machinery -- Discovery -- Structure-Function -- Defects in Nuclear Transport and Disease -- References -- Chapter 7: Myosin: Cellular Molecular Motor -- Discovery -- Structure-Function -- Altered Motor Protein and Disease -- References -- Chapter 8: Assembly of Cellular Nanomachines -- Membrane-Directed Self-Assembly of t-/v-SNARE Ring Complexes -- Biogenesis of Cellular Membranes -- References -- Index
Summary In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the "porosome" nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology
Bibliography Includes bibliographical references and index
Subject Nanoelectromechanical systems.
Nanotechnology.
Secretory Vesicles -- physiology
Secretory Vesicles -- ultrastructure
Cellular Structures -- physiology
Cellular Structures -- ultrastructure
Nanostructures -- ultrastructure
Nanotechnology
Nanoelectromechanical systems
Nanociència.
Nanotecnologia.
Genre/Form Llibres electrònics.
Form Electronic book
ISBN 9783030444969
3030444961
9783030444976
303044497X
9783030444983
3030444988