| Description |
1 online resource (416 p.) |
| Series |
Nanomedicine and Nanotoxicology |
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Nanomedicine and nanotoxicology.
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| Contents |
Intro -- Preface -- Acknowledgments -- Contents -- 1 Introduction -- References -- 2 Drug Conjugation Chemistry in Iron Oxide Nanoparticles (IONPs) -- 2.1 Covalent Drug-Conjugated Iron Oxide Nanoparticles -- 2.1.1 Amide Linkage Drug Conjugation -- 2.1.2 Drug Conjugation with pH-Sensitive Bonding -- 2.1.3 Drug Conjugation with Enzymatically Responsive Bonding -- 2.1.4 Oxidation/Reduction Drug Conjugation -- 2.2 Non-Covalent Drug-Conjugated Iron Oxide Nanoparticles (IONPs) -- 2.2.1 Hydrophobic Drug Conjugation -- 2.2.2 Drug Conjugation Using Electrostatics |
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2.2.3 Drug Conjugation with Encapsulation -- References -- 3 Superparamagnetic Iron Oxide Nanoparticle (SPION) Synthesis -- 3.1 Physical Methods -- 3.1.1 Deposition in the Gas Phase -- 3.1.2 Lithography Using Electronic Beam -- 3.1.3 Laser Ablation with Pulses -- 3.1.4 Pyrolysis Caused by a Laser -- 3.1.5 Strong Ball Milling -- 3.1.6 Combustion -- 3.2 Chemical Methods -- 3.2.1 Chemical Coprecipitation Synthesis -- 3.2.2 Thermolysis (Thermal Decomposition) -- 3.2.3 Microemulsions -- 3.2.4 Synthesis Using Hydrothermal Method -- 3.3 Biological Approach -- References |
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4 Properties of Iron Oxide Nanoparticles (IONPs) -- 4.1 Structural Properties -- 4.1.1 Colloidal Stability -- 4.1.2 Shape and Size -- 4.1.3 Charge of Surface -- 4.2 Magnetic Properties -- 4.3 Thermal Properties -- 4.4 Optical Properties -- 4.4.1 Fluorescence Techniques and Encapsulated IONPs -- References -- 5 Pharmacokinetics of IONPs -- 5.1 Absorption/Uptake -- 5.1.1 Size and Coating Material's Impact on Absorption -- 5.1.2 Charge's Impact on Uptake and Absorption -- 5.1.3 Uptake of IONPs in the Brain -- 5.2 Distribution |
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5.2.1 Iron and IONP Physicochemical Properties Affecting the Distribution -- 5.3 Metabolism -- 5.4 Affecting the Cell Physiology -- 5.4.1 Influence on Cell Proliferation -- 5.4.2 Effect on Stem Cell Differentiation -- 5.4.3 Affects Cell Migration -- 5.5 Excretion -- 5.6 Regulation of Iron in Human -- 5.6.1 Human Body's Iron Flow -- 5.6.2 The Liver Is the Main Organ for Iron Homeostasis -- 5.6.3 Iron Regulation -- 5.6.4 Macrophages Are in Charge of Iron Homeostasis -- 5.6.5 Monocytes and the Iron Metabolism Process -- 5.6.6 Iron-Related Infection and Immunity -- References |
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6 Magnetic Nanoparticles in Stimuli-Responsive Drug Delivery Systems -- 6.1 Drug Delivery Systems with Stimuli-Responsiveness Through Ligand-Mediated MNPs -- 6.1.1 Organic Ligands -- 6.1.2 Inorganic Ligands -- 6.1.3 Hybrid Inorganic-Organic Ligands -- 6.2 The Most Common Methods for Synthesizing MNP-Based Drug Delivery Systems -- 6.2.1 Thin Films Hydration -- 6.2.2 Evaporation Emulsion -- 6.2.3 Solvent Exchange -- References -- 7 IONPs-Based Treatment Methods -- 7.1 Chemotherapy -- 7.2 Stimuli-Responsive Delivery Nanoplatforms -- 7.2.1 Endogenous Stimuli-Responsive Nanoplatforms |
| Summary |
This book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications |
| Notes |
7.2.2 Nanoplatforms That Deliver in Response to Exogenous Stimuli |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 3, 2023) |
| Subject |
Nanoparticles.
|
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Cancer -- Treatment -- Technological innovations.
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Drug delivery systems -- Technological innovations
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Nanoparticles
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Cancer -- Treatment -- Technological innovations.
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Nanoparticles.
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| Form |
Electronic book
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| Author |
Jabali, Ali
|
| ISBN |
9789819965076 |
|
9819965071 |
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