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Title Immunological mechanisms and therapies in brain injuries and stroke / Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang, editors
Published New York, NY : Springer, [2014]


Description 1 online resource (x, 386 pages) : illustrations (some color)
Series Springer Series in Translational Stroke Research
Springer series in translational stroke research.
Contents Old dogmas, surprising complexities, and novel therapeutic targets / Ulrich Dirnagl -- The critical roles of immune cells in acute brain injuries / Peiying Li, Yu Gan, Leilei Mao, Rehana Leak, Jun Chen, and Xiaoming Hu -- Vascular inflammation in ischemic stroke : adhesion receptors controlling leukocyte-endothelial interactions / Stephen F. Rodrigues and D. Neil Granger -- Immune cell-derived free radicals in acute brain injury / Purnima Narasimhan, Hiroyuki Sakata, Joo Eun Jung, Tatsuro Nishi, Takuma Wakai, Carolina M. Maier, and Pak H. Chan -- The complement cascade in acute brain injury / Michael McDowell, Nicholas Shea, Gaurav Gupta, and E. Sander Connolly Jr. -- Matrix metalloproteinases as an inflammatory mediator in the neurovascular unit / Changhong Xing, Takakuni Maki, Ji Hae Seo, Ken Arai, and Eng H. Lo -- Toll-like receptors in ischemic stroke and other acute brain injuries / Frances Rena Bahjat, Raffaella Gesuete, and Mary P. Stenzel-Poore -- Ion transporters in microglial function : new therapeutic targets for neuroinflammation in ischemic stroke? / Hui Yuan, Yejie Shi, and Dandan Sun -- Inflammation after acute brain injuries affects the developing brain differently than the adult brain / David Fernández-López and Zinaida S. Vexler -- Systemic immune responses after experimental stroke / Halina Offner and Patricia D. Hurn -- Infectious burden and risk of stroke / Jorge M. Luna and Mitchell S. V. Elkind -- Inflammatory biomarkers in patients with acute brain injuries / Glen C. Jickling -- In vivo imaging of neuroinflammation in acute brain injury / Alexander Thiel -- Inflammation as a therapeutic target after subarachnoid hemorrhage : advances and challenges / Mutsumi Fujii, Sheng Chen, Damon Klebe, Yoshiteru Soejima, Alexander Vakhmyanin, and John H. Zhang -- Minocycline, a tetracycline derivative, as a potential protective agent for acute stroke / Jari Koistinaho and Milla Koistinaho -- Tolerization to brain and vascular antigens : targeting autoimmunity after acute brain injuries and preventing stroke / Kyra J. Becker and John Hallenbeck -- The role of PPAR[lowercase Greek]Gamma in stroke / Xiurong Zhao and Jaroslaw Aronowski -- CD36 : an inflammatory mediator in acute brain injury / Sunghee Cho and Maria Febbraio -- Cool down the inflammation : hypothermia as a therapeutic strategy for acute brain injuries / Yama Akbari, Maximilian Mulder, Ali Razmara, and Romergryko Geocadin
Summary Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes
Bibliography Includes bibliographical references at chapter ends, and index
Notes Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013)
Subject Brain -- Wounds and injuries -- Treatment
Cerebrovascular disease -- Treatment
Brain Injuries -- therapy
MEDICAL -- Surgery -- General.
Brain -- Wounds and injuries -- Treatment.
Cerebrovascular disease -- Treatment.
Genre/Form Electronic books
Form Electronic book
Author Chen, Jun (Professor of neurology and pharmacology), editor, author.
Hu, Xiaoming, active 2014, editor, author.
Stenzel-Poore, Mary. editor, author.
Zhang, J. H. (John H.), editor, author.
ISBN 9781461489153