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Title Polycystic kidney disease / edited by Jinghua Hu, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, Yong Yu, Department of Biological Sciences, St. John's University, Queens, New York
Published Boca Raton : CRC Press, [2020]
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Description 1 online resource (xiv, 345 pages)
Series Methods in signal transduction
Methods in signal transduction
Summary "This volume focuses on methods applied to autosomal dominant polycystic kidney disease (ADPKD), a common human genetic disease. ADPKD is caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Jinghua Hu is an Associate Professor in Biochemistry and Molecular Biology at the Mayo Clinic in Rochester, Minnesota. He uses various model systems to study the correlation between cilia dysfunction and cilia-related diseases (collectively known as ciliopathies). The long-term goals of Dr. Hu's laboratory are to understand how cilia form and function; determine the pathogenesis underlying ciliopathies; and design therapies to prevent, delay or halt disease progression. The major experimental approaches used in Dr. Hu's laboratory include molecular genetics, biochemistry, real-time imaging and model organisms. Dr. Hu's research has been funded by the National Institutes of Health and PKD Foundation, among other organizations. Yong Yu is an Associate Professor and Graduate Director for Biological Sciences, Molecular and Cellular Physiology and Neurobiology at St John's University. The research in Yu lab is focusing on the molecular mechanisms of assembly, function and regulation of ion channels and membrane receptors. Currently they are interested in the transient receptor potential (TRP) channels, proteins which are essential for sensory physiology and have been shown to play crucial roles in human diseases. So far, TRP channels has been shown to be involved in the formation of sight, hearing, touch, smell, taste, temperature, and pain sensation. They use cultured mammalian cells, Xenopus oocytes and zebrafish as model systems, and study structure and function of ion channels and receptors with a combined molecular biology, biochemistry, biophysics, x-ray crystallography, and electrophysiology approach. Research in Yu lab is funded by the National Institutes of Health
Description based on online resource; title from digital title page (viewed on December 13, 2019)
Subject Polycystic kidney disease -- Genetic aspects
Polycystic kidney disease
Polycystic Kidney Diseases -- genetics
Polycystic Kidney Diseases
MEDICAL / Endocrinology & Metabolism
MEDICAL / Nephrology
Polycystic kidney disease.
SCIENCE / Life Sciences / Cytology
Form Electronic book
Author Hu, Jinghua, editor
Yu, Yong (Biological sciences), editor
LC no. 2019028680
ISBN 0429468830
0429888937
0429888945
0429888953
9780429468834
9780429888939
9780429888946
9780429888953