| Description |
1 online resource : illustrations (black and white, and colour) |
| Contents |
Front Cover -- Chitosan in Drug Delivery -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 Chitosan: source, chemistry, and properties -- 1.1 Introduction -- 1.2 Sources of chitosan -- 1.2.1 Deacetylation of chitin by chemical method -- 1.2.2 Deacetylation of chitin by enzymatic method -- 1.2.3 Deacetylation of chitin by microwave-assisted method -- 1.3 Chemistry of chitosan -- 1.4 Properties of chitosan -- 1.4.1 Physical properties -- 1.4.1.1 Viscosity -- 1.4.1.2 Molecular weight -- 1.4.1.3 Degree of deacetylation -- 1.4.1.4 Stability -- 1.4.1.5 Thermal properties -- 1.4.2 Chemical properties -- 1.4.2.1 Solubility -- 1.4.2.2 pH -- 1.4.2.3 Reactivity -- 1.4.3 Biological properties -- 1.4.3.1 Biocompatibility -- 1.4.3.2 Biodegradability -- 1.4.3.3 Antimicrobial properties -- 1.4.3.4 Antioxidant activity -- 1.4.3.5 Anticancer activity -- 1.4.3.6 Antidiabetic activity -- 1.4.3.7 Blood coagulation effects -- 1.5 Conclusion -- References -- 2 Chitosan-based systems for oral drug delivery applications -- 2.1 Introduction -- 2.2 Chitosan-based oral delivery systems -- 2.2.1 Chitosan-based antiinfective drug delivery -- 2.2.2 Chitosan-based anticancer drug delivery -- 2.2.3 Chitosan-based protein and peptide delivery -- 2.2.4 Chitosan-based gene and nucleic acid delivery -- 2.2.5 Chitosan-based vaccine delivery -- 2.2.6 Miscellaneous -- 2.3 Conclusion and future prospective -- References -- 3 Chitosan-based nanoparticles in drug delivery -- 3.1 Introduction -- 3.2 Chitosan as drug delivery biopolymer -- 3.3 Factors affecting the efficacy of chitosan-based nanoparticles -- 3.4 Applications of chitosan-based nanoparticles for drug delivery -- 3.4.1 Oral delivery -- 3.4.2 Parenteral delivery -- 3.4.3 Topical delivery -- 3.4.4 Target-specific delivery -- 3.5 Conclusions and future prospects -- References |
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4 Role of chitosan in transdermal drug delivery -- 4.1 Introduction -- 4.2 Chitosan-based transdermal drug delivery systems -- 4.2.1 Chitosan-based hydrogel in transdermal drug delivery -- 4.2.2 Chitosan-based microneedle in transdermal drug delivery -- 4.2.3 Chitosan-based thin films in transdermal drug delivery -- 4.2.4 Chitosan-based liposome in transdermal drug delivery -- 4.2.5 Chitosan-based nanoparticles in transdermal drug delivery -- 4.2.6 Chitosan-based electrospun hybrid nanofibers in transdermal drug delivery -- 4.2.7 Chitosan-based emulsion in transdermal drug delivery -- 4.2.8 Chitosan-based gel in transdermal drug delivery -- 4.2.9 Chitosan-based miscellaneous formulation in transdermal drug delivery -- 4.3 Conclusion -- References -- 5 Chitosan in colon-targeted drug delivery -- 5.1 Introduction -- 5.2 Mechanism of action of chitosan on colonic mucosa -- 5.3 Chitosan as colon-specific drug carrier biopolymeric material -- 5.3.1 Native chitosan -- 5.3.2 Carboxymethyl chitosan -- 5.3.3 Trimethyl chitosan -- 5.3.4 N-succinyl chitosan -- 5.3.5 Thiolated chitosan -- 5.3.6 PEGylated chitosan -- 5.3.7 Folic acid-conjugated chitosan -- 5.3.8 Hyaluronic acid-coupled chitosan -- 5.3.9 Other chitosan-based systems -- 5.4 Conclusion -- References -- 6 Chitosan as a biomaterial for implantable drug delivery -- 6.1 Introduction -- 6.2 Implantable drug delivery system -- 6.2.1 Implantable pump technique -- 6.2.1.1 Osmotic pumps -- 6.2.1.2 Infusion pumps -- 6.2.1.3 Nonbiodegradable implants -- 6.2.1.4 Biodegradable implants -- 6.2.2 Insertable drug delivery systems -- 6.2.2.1 Intraocular implants -- 6.2.2.2 Intrauterine and vaginal implants -- 6.3 Nontypical implantable drug delivery system -- 6.3.1 Microfabricated or nanofabricated implantable drug delivery system -- 6.3.2 Ceramic drug delivery system -- 6.4 Chitosan: as a biomaterial |
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6.4.1 Synthesis of chitosan -- 6.4.2 Properties based on structure -- 6.4.3 Chitosan in implant drug delivery -- 6.5 Conclusion -- Acknowledgment -- Conflict of Interest -- References -- 7 Chitosan-based drug delivery systems in cancer therapeutics -- 7.1 Introduction -- 7.2 Sources and isolation of chitosan -- 7.2.1 Sources of chitosan -- 7.2.2 Isolation of chitosan from chitin -- 7.2.2.1 Isolation of chitosan from chitin by chemical method -- 7.2.2.2 Isolation of chitosan from chitin by enzymatic method -- 7.3 Chemical structure and properties of chitosan -- 7.4 Chitosan: as a polymer in anticancer treatment -- 7.4.1 Limitations of chitosan in anticancer therapy -- 7.5 Different chemical derivatives of chitosan having anticancer activities -- 7.6 Targeting of nanotherapeutics -- 7.6.1 Passive targeting -- 7.6.2 Active targeting -- 7.7 Conclusion -- References -- 8 In situ gelling systems of chitosan for potential drug delivery applications -- 8.1 Introduction -- 8.2 Various chitosan-mediated in situ gel systems -- 8.2.1 Gel with microparticle-based systems -- 8.2.2 Gel (polymeric/nonpolymeric) systems -- 8.2.3 Gel containing nanoparticles -- 8.2.4 Gel containing lipid/polymer-based systems -- 8.2.5 Hydrogel systems -- 8.2.6 Mucoadhesive gel systems -- 8.2.7 Scaffold systems -- 8.2.8 Miscellaneous -- 8.3 Conclusion and future scope -- References -- 9 Chitosan as mucoadhesive polymer in drug delivery -- 9.1 Introduction -- 9.2 Mucoadhesion -- 9.2.1 Mucus -- 9.2.2 Interaction of mucoadhesives and mucosa -- 9.2.2.1 Chemical bonds -- 9.2.2.2 Theories of mucoadhesion -- 9.3 Chitosan as polymeric excipients -- 9.4 Chitosan and its derivatives as mucoadhesive agents -- 9.4.1 Chitosan as mucoadhesive -- 9.4.2 Thiolated chitosan -- 9.4.3 Trimethyl chitosan -- 9.4.4 Hydrophobically modified chitosans -- 9.4.5 PEGylated chitosan -- 9.5 Conclusion -- References |
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10 Thiolated chitosan as an improved bioadhesive polymer in drug delivery -- 10.1 Introduction -- 10.2 Synthesis of thiolated chitosan -- 10.3 Thiolated chitosan derivatives -- 10.3.1 Chitosan-cysteine -- 10.3.2 Chitosan-TBA -- 10.3.3 Chitosan-TGA -- 10.3.4 Chitosan-N-acetyl cysteine -- 10.3.5 Chitosan-glutathione -- 10.3.6 Chitosan-6-mercaptonicotinic acid -- 10.3.7 Chitosan-4-mercaptobenzoic acid -- 10.4 Properties of thiolated chitosan -- 10.4.1 Mucoadhesive property -- 10.4.2 Cohesive property (in situ gelling property) -- 10.4.3 Permeation enhancing property -- 10.4.4 Enzyme and efflux protein inhibition properties -- 10.5 Applications of thiolated chitosan -- 10.5.1 Controlled drug delivery system -- 10.5.2 Noninvasive peptide delivery -- 10.5.3 Site-specific delivery -- 10.5.4 Polysaccharide coating of nanoparticles -- 10.5.5 DNA delivery -- 10.5.6 Wound dressing -- 10.5.7 Ocular delivery of therapeutics -- 10.5.8 Tissue engineering -- 10.6 Conclusion and future perspective -- References -- 11 Cross-linking of chitosan in drug delivery -- 11.1 Introduction -- 11.2 General properties of chitosan -- 11.3 The limitations of native chitosan as a carrier in drug delivery system -- 11.4 Cross-linking of chitosan -- 11.4.1 Chemical cross-linking -- 11.4.1.1 Glutaraldehyde -- 11.4.1.2 Genipin -- 11.4.1.3 Glyoxal -- 11.4.1.4 Dextran sulfate -- 11.4.1.5 Bifunctional cross-linking agents -- 11.4.2 Physical cross-linking -- 11.4.2.1 Tripolyphosphate -- 11.4.3 Radiation cross-linking -- 11.5 Conclusion -- References -- 12 Graft copolymers of chitosan in drug delivery applications -- 12.1 Introduction -- 12.2 Chitosan: structure and chemistry -- 12.3 Rational for graft copolymerizations of chitosan -- 12.4 Various graft copolymers of chitosan in drug delivery -- 12.5 Conclusions -- References |
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13 Carboxymethyl chitosan in advanced drug-delivery applications -- 13.1 Introduction -- 13.2 Applications of carboxymethyl chitosan and its derivatives -- 13.2.1 Antiinfective -- 13.2.1.1 Antibacterial -- 13.2.1.2 Antifungal -- 13.2.2 Antitumor and anticancer -- 13.2.3 Antioxidant -- 13.2.4 Antiinflammatory -- 13.2.5 Organ targeting -- 13.2.5.1 Colon targeting -- 13.2.5.2 Liver targeting -- 13.2.5.3 Lung targeting -- 13.2.5.4 Nervous tissues -- 13.2.5.5 Ocular targeting -- 13.2.6 Bone and cartilage -- 13.2.7 Wound healing -- 13.2.8 Bioimaging -- 13.2.9 Cosmetics -- 13.3 Conclusions and future prospects -- References -- 14 Chitosan-based hydrogels in drug delivery -- 14.1 Introduction -- 14.2 Chitosan as biopolymer -- 14.3 Preparation of chitosan-based hydrogels -- 14.3.1 Physical crosslinking -- 14.3.2 Chemical crosslinking -- 14.4 Drug delivery applications of chitosan hydrogels -- 14.4.1 Oral drug delivery -- 14.4.2 Localized drug delivery in the oral cavity -- 14.4.3 Colonic drug delivery -- 14.4.4 Ophthalmic drug delivery -- 14.4.5 Transdermal drug delivery -- 14.4.6 Nasal drug delivery -- 14.4.7 Drug delivery in cancer therapy -- 14.5 Conclusion -- References -- 15 Chitosan as a responsive biopolymer in drug delivery -- 15.1 Introduction -- 15.2 Responsive polymers -- 15.3 Chitosan -- 15.4 Chitosan-based responsive carrier systems for drug delivery -- 15.4.1 Chitosan-based pH-responsive systems -- 15.4.2 Chitosan-based temperature-responsive systems -- 15.4.3 Chitosan-based pH- and temperature-responsive systems -- 15.4.4 Chitosan-based pH- and ionic-responsive systems -- 15.4.5 Chitosan-based magnetic-responsive systems -- 15.5 Conclusion -- References -- 16 Chitosan-based nanobiocomposites in drug delivery -- 16.1 Introduction -- 16.2 Nanobiocomposites -- 16.3 Chitosan -- 16.4 Chitosan-based nanobiocomposites |
| Summary |
Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan -- provided by publisher |
| Notes |
Print version record |
| Subject |
Chitosan -- Industrial applications
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Chitosan -- Biotechnology
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Drug delivery systems.
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Drug Delivery Systems
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Chitosan -- Biotechnology
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Drug delivery systems
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| Form |
Electronic book
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| Author |
Hasnain, Md Saquib, 1984- editor.
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Nayak, Amit Kumar, 1979- editor.
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Beg, Sarwar, 1987- editor.
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| ISBN |
0128193379 |
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9780128193372 |
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