| Description |
1 online resource |
| Contents |
Cover; Title Page; Copyright Page; Dedication; Contents; Acknowledgments; Chapter 1 -- An introduction to fermentation processes; The range of fermentation processes; Microbial biomass; Microbial enzymes; Microbial metabolites; Recombinant products; Transformation processes; The chronological development of the fermentation industry; The component parts of a fermentation process; References; Chapter 2 -- Microbial growth kinetics; Batch culture; Exponential phase; Deceleration and stationary phases; Continuous culture; Multistage systems; Feedback systems; Internal feedback; External feedback |
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Comparison of batch and continuous culture in industrial processesBiomass productivity; Metabolite productivity; Continuous brewing; Continuous culture and biomass production; Comparison of batch and continuous culture as investigative tools; Fed-batch culture; Variable volume fed-batch culture; Fixed volume fed-batch culture; Fed-batch culture at a constant specific growth rate; Cyclic fed-batch culture; Application of fed-batch culture; Examples of the use of fed-batch culture; References; Chapter 3 -- The isolation and improvement of industrially important microorganisms |
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Isolation of industrially important microorganismsIsolation methods utilizing selection of the desired characteristic; Enrichment liquid culture; Enrichment cultures using solidified media; Isolation methods not utilizing selection of the desired characteristic-from the "Waksman platform" to the 1990s; Screening methods and high throughput screening; Return of natural products; Broadening the base of the discovery process and maximizing gene expression; Improvement of industrial microorganisms; Improvement of strains producing primary biosynthetic products |
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Selection of induced mutants synthesizing improved levels of primary metabolitesIsolation of Corynebacterium glutamicum and the role of permeability in the glutamate fermentation; Isolation of mutants that do not produce feedback inhibitors or repressors; Isolation of mutants that do not recognize the presence of inhibitors and repressors; The use of recombination systems for the improvement of primary metabolite production; Transduction, transformation, and protoplast fusion; Recombinant DNA technology |
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Postgenomic era-the influence of genomics, transcriptomics, and fluxomics on the improvement of primary metabolite producersApplication of genomics; Application of transcriptomics; Application of metabolic flux analysis and a systems biology approach; Improvement of strains producing secondary biosynthetic products; Isolation of mutants producing improved yields of secondary metabolites; The empirical approach; Use of directed selection in the isolation of improved secondary metabolite producers; Use of recombination systems for the improvement of secondary metabolite production |
| Summary |
The successful structure of the previous edition of Principles of Fermentation Technology has been retained in this third edition, which covers the key component parts of a fermentation process including growth kinetics, strain isolation and improvement, inocula development, fermentation media, fermenter design and operation, product recovery, and the environmental impact of processes. This accurate and accessible third edition recognizes the increased importance of animal cell culture, the impact of the post-genomics era on applied science and the huge contribution that heterologous protein production now makes to the success of the pharmaceutical industry. This title is ideally suited for both newcomers to the industry and established workers as it provides essential and fundamental information on fermentation in a methodical, logical fashion. Stanbury, Whitaker and Hall have integrated the biological and engineering aspects of fermentation to make the content accessible to members of both disciplines with a focus on the practical application of theory. This text collates all the fermentation fundamentals into one concise reference, making it a valuable resource for fermentation scientists, as well as those studying in the field |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed September 27, 2016) |
| Subject |
Fermentation.
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Fermentation
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Fermentation
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| Form |
Electronic book
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| Author |
Whitaker, Allan, author.
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Hall, Stephen J. (College teacher), author.
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| ISBN |
9780444634085 |
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0444634088 |
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