| Description |
1 online resource |
| Contents |
Preface; Contents; Contributors; Molecular and Clinical Characterization of Gliomas; 1 Use of Advanced Neuroimaging (fMRI, DTI/Tractography) in the Treatment of Malignant Gliomas; Functional MRI; Task-Based fMRI; Resting State fMRI; Motor Mapping Using fMRI; Supplementary Motor Area; Language fMRI; Language Lateralization; Language Localization; Technical Considerations; Diffusion Tractography; Cortico-Spinal Tract; Arcuate Fasciculus; Visual Projections; Limitations; References; 2 Molecular Neuropathology and the Ontogeny of Malignant Gliomas; Introduction |
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2016 WHO Classification-Integrated Diagnostics; Diffuse Astrocytic and Oligodendroglial Gliomas; Histological Profiles of Diffuse Astrocytic and Oligodendroglial Tumors; Diffuse Astrocytic Tumors; Diffuse Oligodendroglial Tumors; Diffuse Oligoastrocytomas; Molecular Profiles of Diffuse Astrocytic and Oligodendroglial Tumors; Isocitrate Dehydrogenase (IDH) Mutations; Co-deletion of 1p/19q; MGMT Methylation Status; Role of Epidermal Growth Factor Receptor (EGFR) Pathway Aberrations; Diffuse Midline Glioma; Ependymal Tumors; Molecular Profiles of Ependymal Tumors; Disclosures; References |
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3 Personalized Medicine Through Advanced Genomics; Introduction; Advanced Genomic Technologies; Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES); Bioinformatic Analysis of NGS; Gene Expression Studies; Proteomics; Genomic Approaches to Personalized Medicine; Insights on Malignant Brain Tumors from Genomic Studies; Glioblastoma Multiforme; Medulloblastoma; Meningioma; Tumor Heterogeneity and the Need for Personalized Approaches; Future Directions and Challenges; References; Surgery: Maximizing the Extent of Tumor Resection |
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4 The Usefulness of Stereotactic Neuronavigation Along with Intraoperative Imaging in Malignant Brain Tumor Surgery; Introduction; Stereotactic Neuronavigation; Intraoperative Ultrasound (iUS); Intraoperative Magnetic Resonance Imaging (iMRI); Intraoperative Angiography (iA); Summary; References; 5 Mapping the Brain for Primary Brain Tumor Surgery; Introduction; Preoperative Mapping; Preoperative Cortical Methods; Task-Based fMRI (T-fMRI); Rest-Based fMRI (R-fMRI); rTMS: Motor/Language; Preoperative Axonal Mapping; Intraoperative Mapping; Cortical Mapping Under General Anesthesia |
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Motor: DES Versus Train of Five; Non-motor Functions: Cortico-Cortical Evoked Potentials; Cortical Mapping in Awake Condition; Sensori-Motor Functions; Primary Visual Areas; Language; Spatial Consciousness; Calculation; Double Task; Mentalizing; Other Self-reported Effects of Stimulations; Axonal Mapping Under General Anesthesia; Motor: DES Versus Train of Five; Non-motor Functions: ACEPs; Axonal Mapping in Awake Patients; Motor Functions; Language Function; Visual Functions; Spatial Consciousness; Mentalizing; Mental Calculation; Plasticity and Remapping; Conclusions; References |
| Summary |
This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping, and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors. More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents, and personalized cancer treatment. In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they are needed most. Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients, as well as those who are training for a career in managing patients with these challenging tumors |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed January 11, 2017) |
| Subject |
Brain -- Tumors.
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Brain -- Cancer.
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Brain Neoplasms -- therapy
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Brain Neoplasms
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Brain -- Cancer
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Brain -- Tumors
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| Form |
Electronic book
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| Author |
Gunel, Jennifer Moliterno, editor
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Piepmeier, J. M., editor.
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Baehring, Joachim M., editor.
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| ISBN |
9783319498645 |
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3319498649 |
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