| Description |
1 online resource (x, 345 pages) : illustrations (some color) |
| Contents |
Machine generated contents note: Chapter 1 -- Introduction: From G-Quartet to G-Quadruplex and its Nanoarchitectures / Lea Spindler -- Guanylic acid Self-Assembly: 100 years on / Gang Wu -- Functional Assemblies made from Supramolecular G-Quadruplexes / J.M. Rivera -- Self-Assembly of Lipophilic Guanosines: Switching between different Assemblies / Gian Piero Spada -- Nanopatterning the Surface with ordered Supramolecular Architectures: Controlling the Self-Assembly of Guanine-based Hydrogen-Bonded Motifs / Paolo Samor -- Morphological Heterogeneity of Supramolecular G-DNA Polymers derived from Guanine Rich Oligonucleotides / M.A. Klimstra -- Thermondynamics of G-Quadruplexes / C. Giancola -- G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods / Hiroshi Sugiyama -- Chapter 2 -- Introduction: Synthesis and Characterization / Gian Piero Spada -- Synthesis and Properties of Oligonucleotides Forming G-Quadruplexes / R. Eritja |
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Electrochemical Characterization of Guanine Quadruplexes / A.M. Oliveira-Brett -- AFM of Guanine Rich Oligonucleotide Surface Structures / James Vesenka -- Solution Dynamics and Structure of G-Quadruplexes Studied by Dynamic Light Scattering / Lea Spindler -- GMP-Quadruplex Structures in Dilute Solutions and in Condensed Phases: An X-Ray Scattering Analysis / P. Mariani -- Temperature-Gradient Gel Electrophoresis: Unfolding of G-Quadruplexes / L'ubos Bauer -- Specific Behaviour of Guanosine in Liponucleoside Thin Films / I. Drevensek-Olenik -- Chapter 3 -- Theoretical Modelling, Analysis and Prediction / Shozeb Haider -- Fundamentals and Applications of the Geometric Formalism of Quadruplex Folding / Andreas Ioannis Karsisiotis -- Guanine, Xanthine and Uric Acid Assemblies: Comparative Theoretical and Experimental Studies / Lajos Kovacs -- Computational Methods for Studying G-Quadruplex Nuceic Acids / S. Haider -- Chapter 4 |
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Introduction: Recognition of Quadruplexes / Mateus Webba da Silva -- Biological Functions of G-Quadruplexes / Nancy Maizels -- Regulation of Gene Transcription by DNA G-Quadruplexes / Michael Fry -- The Reality of Quadruplex Nucleic Acids as a Therapeutic Target / G.N. Parkinson -- Screening for Quadruplex Binding Ligands: A Game of Chance? / M.-P. Teulade-Fichou -- Recognition of G-Quadruplexes by Metal Complexes / Ramon Vilar -- Chapter 5 -- Introduction: Applications in Bioanalytics, Therapy and Molecular Electronics / Wolfgang Fritzsche -- Catalytic G-Quadruplexes / Dipankar Sen -- Catalytic G-Quadruplexes for the Detection of Telomerase Activity / Bernard Juskowiak -- G-Quadruplex forming Oligonucleotides with Tailor-made Modifications as effective aptamers for Potential Therapeutic Applications / Daniela Montesarchio -- Dep-Based Integration of G-Quadruplex Structures / Wolfgang Fritzsche -- Conductive Behaviour of G4-DNA-Silver Nanoparticle Structures / J.J. Toppari |
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Novel Materials for Molecular Electronics -- Synthese and Characterization of Long G4-DNA / Danny Porath |
| Summary |
"Guanosine and its derivatives have a high potential for self-recognition and self-assembly, as well as the recognition ability for other biologically important molecules. This book explores in detail these properties with the goal of increasing knowledge of the basic principles of guanosine-assembly, synthesis of new optimised materials and exploration of their electronic and optical properties. Following the work of COST Action MP0802, the aim is to design novel reproducible and well ordered supramolecular structures to serve as molecular-scale architectures for new hybrid molecular electronics. Coverage includes synthesis, characterisation and optimisation, theoretical modelling and prediction, biochemical and biorecognition properties and applications in nanotechnology especially in molecular electronics. Appealing to researchers working in the field ranging from chemists, biologists and material scientists, this title will be a welcome addition to the inter-disciplinary literature providing direction for future research and ideas for industrial applications."-- Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record and online resource (viewed Feb. 11, 2013) |
| Subject |
Quadruplex nucleic acids.
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Molecular structure.
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Nucleic Acid Conformation
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Genetic Structures
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Molecular Conformation
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Molecular Structure
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Genetic Phenomena
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Biochemical Phenomena
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Phenomena and Processes
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Chemical Phenomena
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G-Quadruplexes
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molecular structure.
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Chemistry.
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Materials science.
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SCIENCE -- Chemistry -- Organic.
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Molecular structure
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Quadruplex nucleic acids
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| Form |
Electronic book
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| Author |
Fritzsche, Wolfgang.
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Spindler, Lea
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| ISBN |
9781849736954 |
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1849736952 |
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