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Book Cover
E-book
Author Focosi, Daniele, 1980-

Title SARS-CoV-2 spike protein convergent evolution : impact of virus variants on efficacy of COVID-19 therapeutics and vaccines / Daniele Focosi
Published Cham : Springer, 2021

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Description 1 online resource (140 pages)
Series SpringerBriefs in microbiology
SpringerBriefs in microbiology.
Contents Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion
Summary This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (Library Ideas, viewed October 22, 2021)
Subject COVID-19 (Disease)
Medical virology.
COVID-19
COVID-19 (Disease)
Medical virology
Vacunes.
COVID-19.
Llibres electrònics.
Genre/Form Llibres electrònics.
Form Electronic book
ISBN 9783030873240
3030873242