| Description |
1 online resource (xv, 565 pages) : illustrations (some color) |
| Series |
Methods in Molecular Biology, 1940-6029 ; v. 1646 |
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Methods in molecular biology (Clifton, N.J.) ; v. 1646. 1064-3745
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| Contents |
880-01 Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders -- Preanalytical Issues in Hemostasis and Thrombosis Testing -- The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing -- Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR) -- Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants -- Performance and Interpretation of Mixing Tests in Coagulation -- D-Dimer Testing: Laboratory Aspects and Current Issues -- Determination of Fibrinogen and Thrombin Time (TT) -- An Overview of Thrombophilia and Associated Laboratory Testing -- Laboratory Testing for Activated Protein C Resistance (APCR) -- Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing -- Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing -- Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing -- Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT) -- Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT) -- Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies -- Solid Phase Immunoassay for the Detection of Anti-?2 Glycoprotein I Antibodies -- Measuring Direct Oral Anticoagulants -- Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing -- One-Stage Factor VIII Assays -- Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A -- Assessment of Factor XIII -- Detection and Measurement of Factor Inhibitors -- Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages and Disadvantages -- Platelet Function Analyzed by Light Transmission Aggregometry -- Whole Blood Platelet Aggregometry -- Assessment of Platelet Function in Whole Blood by Flow Cytometry -- Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood -- Diagnosis or Exclusion of Von Willebrand Disease Using Laboratory Testing -- Laboratory Testing for Von Willebrand Factor Antigen (VWF:Ag) -- Laboratory Testing for Von Willebrand Factor Collagen Binding (VWF:CB) -- Laboratory Testing for Von Willebrand Factor Ristocetin Cofactor (VWF:RCo) -- Laboratory Testing for Von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb) -- Laboratory Testing for Von Willebrand Factor Factor VIII Binding (for 2N VWD) -- Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies -- Laboratory Testing for Von Willebrand Factor Multimers -- Thrombin Generation Assays (TGA) -- The Overall Haemostatic Potential (OHP) Assay -- Thromboelastography (TEG) -- Post-Analytical Issues in Hemostasis and Thrombosis Testing |
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880-01/(S Overview of hemostasis and thrombosis and contribution of laboratory testing to diagnosis and management of hemostasis and thrombosis disorders / Roslyn A. Bonar, Giuseppe Lippi, and Emmanuel J. Favaloro -- Preanalytical issues in hemostasis and thrombosis testing / Giuseppe Lippi and Emmanuel J. Favaloro -- Interface between immunotransfusion and hemostasis and thrombosis testing / Massimo Franchini -- Optimizing the verification of mean normal prothrombin time (MNPT) and international sensitivity index (ISI) for accurate conversion of prothrombin time (PT) to international normalized ratio (INR) / Emmanuel J. Favaloro -- Performance of activated partial thromboplastin time (APTT) : determining reagent sensitivity to factor deficiencies, heparin, and lupus anticoagulants / Geoffrey Kershaw -- Performance and interpretation of mixing tests in coagulation / Geoffrey Kershaw -- D-dimer testing : laboratory aspects and current issues / Jecko Thachil, Giuseppe Lippi, and Emmanuel J. Favaloro -- Determination of fibrinogen and thrombin time (TT) / Anetta Undas -- Overview of thrombophilia and associated laboratory testing / Martina Montagnana, Giuseppe Lippi, and Elisa Danese -- Laboratory testing for activated protein C resistance (APCR) / Soma Mohammed and Emmanuel J. Favaloro -- Assessment of hereditary thrombophilia : performance of protein C (PC) testing / Richard A. Marlar and Jana N. Gausman -- Assessment of hereditary thrombophilia : performance of protein S (PS) testing / Richard A. Marlar and Jana N. Gausman -- Assessment of hereditary thrombophilia : performance of antithrombin (AT) testing / Jana N. Gausman and Richard A. Marlar -- Lupus anticoagulant testing : diluted Russell viper venom time (dRVVT) / Vittorio Pengo, Elisa Bison, Alessandra Banzato, Giacomo Zoppellaro, Seena Padayattil Jose, and Gentian Denas -- Lupus anticoagulant testing : activated partial thromboplastin time (APTT) and silica clotting time (SCT) / Armando Tripodi and Veena Chantarangkul -- Solid phase immunoassay for the detection of anticardiolipin antibodies / Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris -- Solid phase immunoassay for the detection of anti-β2 glycoprotein I antibodies / Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris -- Measuring direct oral anticoagulants / Robert C. Gosselin and Jonathan Douxfils -- Laboratory testing protocols for heparin-induced thrombocytopenia (HIT) testing / Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, and Emmanuel J. Favaloro -- One-stage factor VIII assays / Elizabeth Duncan and Susan Rodgers -- Chromogenic factor VIII assays for improved diagnosis of hemophilia A / Susan Rodgers and Elizabeth Duncan -- Assessment of factor XIII / László Muszbek, Éva Katona, and Adrienne Kerényi -- Detection and measurement of factor inhibitors / Geoffrey Kershaw -- Platelet function tests : preanalytical variables, clinical utility, advantages, and disadvantages / Anne-Mette Hvas and Erik Lerkevang Grove -- Platelet function analyzed by light transmission aggregometry / Anne-Mette Hvas and Emmanuel J. Favaloro -- Whole blood platelet aggregometry / George A. Fritsma and David L. McGlasson -- Assessment of platelet function in whole blood by flow cytometry / Leonardo Pasalic -- Flow cytometry protocols for assessment of platelet function in whole blood / Leonardo Pasalic, Gabrielle J. Pennings, David Connor, Heather Campbell, Leonard Kritharides, and Vivien M. Chen -- Diagnosis or exclusion of von Willebrand disease using laboratory testing / Emmanuel J. Favaloro -- Laboratory testing for von Willebrand factor antigen (VWF:Ag) / Emmanuel J. Favaloro, Soma Mohammed, and Jürgen Patzke -- Laboratory testing for von Willebrand factor collagen binding (VWF:CB) / Emmanuel J. Favaloro and Soma Mohammed -- Laboratory testing for von Willebrand factor ristocetin cofactor (VWF:RCo) / Soma Mohammed and Emmanuel J. Favaloro -- Laboratory testing for von Willebrand factor activity by glycoprotein Ib binding assays (VWF:GPIb) / Jürgen Patzke and Emmanuel J. Favaloro -- Laboratory testing for von Willebrand factor : factor VIII binding (for 2N VWD) / Soma Mohammed and Emmanuel J. Favaloro -- Ristocetin-induced platelet aggregation (RIPA) and RIPA mixing studies / Juan Pablo Frontroth and Emmanuel J. Favaloro -- Laboratory testing for von Willebrand factor multimers / Susan Oliver, Kun Kan Edwin Lau, Kent Chapman, and Emmanuel J. Favaloro -- Thrombin generation assays (TGAs) / Gian Luca Salvagno and Erik Berntorp -- Overall hemostatic potential (OHP) assay / Jennifer Curnow -- Thromboelastography (TEG) / Maha Othman and Harmanpreet Kaur -- Post-analytical issues in hemostasis and thrombosis testing / Emmanuel J. Favaloro and Giuseppe Lippi |
| Summary |
This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerProtocol, viewed August 16, 2017) |
| Subject |
Hemostasis -- Laboratory manuals
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Thrombosis -- Laboratory manuals
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Hemostasis.
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Hemostasis
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Thrombosis -- diagnosis
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Medical research.
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Science -- Life Sciences -- Biology -- Molecular Biology.
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Hemostasis
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Thrombosis
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| Genre/Form |
Laboratory manuals
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Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Favaloro, Emmanuel J., editor
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Lippi, Giuseppe, editor
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| ISBN |
9781493971961 |
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1493971964 |
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