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Title Vertebrate motoneurons / Michael J. O'Donovan, Mélanie Falgairolle, editors
Published Cham : Springer, 2022


Description 1 online resource (403 pages)
Series Advances in neurobiology ; v. 28
Advances in neurobiology ; 28.
Contents Intro -- Preface -- Contents -- Part I: Motoneuron Development -- Establishing the Molecular and Functional Diversity of Spinal Motoneurons -- 1 Introduction -- 2 Anatomical and Functional Diversity of Spinal Motoneurons -- 3 Specification of Spinal Motoneuron Class Identity -- 4 Early Patterning of Spinal Motoneurons Along the Rostrocaudal Axis -- 5 Developmental Mechanisms of Motoneuron Diversification -- Hox Genes and the Specification of LMC Neurons and Divisional Subtypes -- Intrinsic Programs of Motoneuron Pool Specification -- Target-Dependent Regulation of Motoneuron Pool Identities
Development of Phrenic Motor Column (PMC) Neurons -- Development and Diversity of Preganglionic Column (PGC) Neurons -- Specification Hypaxial (HMC) and Medial Motor Column (MMC) Neurons -- Establishing Motoneuron Functional Subtype Diversity -- 6 Evolution of Spinal Motoneuron Organization and Function -- Origins of Tetrapod Limb Motoneurons -- Hox Genes and the Evolution of Motoneuron Segmental Organization and Diversity -- Divergence of Axial Motoneuron Specification Programs in Fish -- 7 Assembly of Proprioceptive Sensory-Motor Circuits
Specification of Proprioceptor Sensory Neuron Class Identities -- Target-Derived Signals Regulate pSN Subtype Identity and Connectivity with Motoneurons -- Roles of Motoneuron Subtype Identity in Sensory-Motor Circuit Assembly -- Evidence for Coordinate Regulation of pSN-Motoneuron Connectivity by Hox Genes -- 8 Motoneurons as Regulators of Circuit Assembly and Function -- 9 Conclusions -- References -- Chloride Homeostasis in Developing Motoneurons -- 1 Introduction -- 2 NKCC1 and KCC2 Molecular Properties -- 3 Chloride Homeostasis in Developing Motoneurons -- Anatomical Maturation of CCCs
Modulation of the Chloride Homeostasis in Developing Motoneurons -- Functional Consequences -- 4 Pathological Considerations -- 5 Concluding Remarks -- References -- Normal Development and Pathology of Motoneurons: Anatomy, Electrophysiological Properties, Firing Patterns and Circuit Connectivity -- 1 Introduction and Historical Retrospective -- 2 Classification of Motoneurons -- 3 The Development of the Electrophysiological Properties and Firing Patterns of Motoneurons -- 4 Development of Motoneuron Spinal Cord Circuitry -- 5 Motoneuron Function Is Altered in Disease States -- References
Homeostatic Regulation of Motoneuron Properties in Development -- 1 Introduction -- 2 Chick Embryo Homeostatic Plasticity -- Synaptic Scaling -- Homeostatic Intrinsic Plasticity -- 3 Translation of Findings in Chick Embryo to Other Systems -- Nicotine Exposure to Developing Rat Hypoglossal Motoneurons -- Scaling Induced in Zebrafish Motoneurons Did Not Alter Motor Activity -- Altered Levels of Neurotransmission Can Trigger HIP in Fly Motoneurons -- 4 Novel Homeostatic Principles in Motoneurons from Studies in the Developing Fly and Frog
Summary This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease. Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered. This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons
Notes Identification of Signaling Pathways in Fly Embryo Motoneurons
Online resource; title from PDF title page (SpringerLink, viewed September 15, 2022)
Subject Motor neurons.
Motor neurons.
Genre/Form Electronic books
Form Electronic book
Author O'Donovan, Michael J
Falgairolle, Mélanie
ISBN 9783031071676