| Description |
1 online resource (673 p.) |
| Contents |
Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface to the Sixth Edition -- Chapter 1 Introduction: Two Centuries of Progress in Transfusion Medicine -- Blood Donation Worldwide -- Changing Landscape of Transfusion Risks -- Immunohaematology -- Clinical Use of Blood Components: Evolution Based on Evidence -- Urgent Transfusion -- Patients Requiring Chronic Transfusion Support -- Obstetric, Neonatal and Paediatric Transfusion Medicine -- Haemostasis and Transfusion -- Cellular Therapies, Transplantation, Apheresis -- The Future -- Conclusion -- References |
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Chapter 2 Essential Immunology for Transfusion Medicine -- Cellular Basis of the Immune Response -- Innate Immune Cells -- Adaptive Immune Cells -- B-Cell Activation and T-Cell-Dependent Antibody Formation -- Humoral Immune Response -- Basis of Antibody Variability -- Antibody Effector Functions -- Red Blood Cell Antibodies Illustrating These Principles -- Antibody and Complement-Mediated Blood Cell Destruction -- Clinical Aspects Related to Alloimmunisation against Blood Cell Antigens -- Acknowledgement -- References -- Further Reading -- Chapter 3 Human Blood Group Systems -- The ABO System |
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Clinical Significance -- Biosynthesis and Molecular Genetics -- H, the Biochemical Precursor of A and B -- The Rh System -- Rh Genes and Proteins -- D Antigen -- Anti-D -- Prediction of Fetal Rh Phenotype by Molecular Methods -- C and c, E and e -- Other Rh Antigens -- Other Blood Group Systems -- Kell System -- Duffy System -- Kidd System -- MNS System -- Biological and Clinical Significance of Blood Group Antigens -- References -- Further Reading -- Chapter 4 Human Leukocyte Antigens -- HLA Class I Genes -- HLA Class II Genes -- Genetic Organisation and Expression of HLA Class II Genes |
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Expression of HLA Molecules -- Genetics -- Function of HLA Molecules -- HLA Nomenclature, Gene Polymorphism and Molecular HLA Typing -- PCR Sequence-Specific Priming -- PCR Sequence-Specific Oligonucleotide Probing -- DNA Sequencing-Based Typing -- Formation of HLA Antibodies -- HLA Antibody Detection -- CDC/Microlymphocytotoxicity Assay -- Solid-Phase Antibody Detection Assays -- Crossmatching for Compatibility Evaluation -- Physical Crossmatches -- Virtual Crossmatches -- HLA and Solid Organ Transplantation -- HLA and Haematopoietic Stem Cell Transplantation -- HLA and Blood Transfusion |
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HLA and Disease Association -- HLA and Pharmacogenomics -- Acknowledgements -- References -- Further Reading -- Chapter 5 Platelet and Neutrophil Antigens -- Antigens on Platelets and Neutrophils -- Human Platelet Antigens -- Inheritance and Nomenclature -- Typing for HPAs -- Platelet Isoantigens, Autoantigens and Drug-Dependent Antigens -- Detection of HPA Alloantibodies -- Clinical Significance of HPA Alloantibodies -- Fetal and Neonatal Alloimmune Thrombocytopenia -- Human Neutrophil Antigens -- HNA-1 -- HNA-2 -- HNA-3 -- HNA-4 and HNA-5 -- Detection of Neutrophil Antibodies |
| Notes |
Description based upon print version of record |
|
Clinical Significance of HNA Antibodies |
| Form |
Electronic book
|
| Author |
Roberts, David J
|
|
Yazer, Mark H
|
|
Dunbar, Nancy M
|
| ISBN |
9781119665830 |
|
1119665833 |
|
