Foreword; Preface; Contents; Contributors; Introduction to Simulation for Design of Clinical Trials; Input-Output Models; Defining Covariate Distribution Models for Clinical Trial Simulation; Protocol Deviations and Execution Models; Determination of Model Appropriateness; Computational Considerations in Clinical Trial Simulations; Analysis of Simulated Clinical Trials; Sensitivity Analysis of Pharmacokinetic and Pharmacodynamic Models in Clinical Trial Simulation and Design; Choice of Best Design; Clinical Trial Simulation (CTS); Academic Perspective
Summary
This text details essential components of performing simulation for designing clinical trials via pharmacokinetic-pharmacodynamic modelling. It offers a range of applications for optimizing sampling strategies, selecting dosage and predicting drug efficacy and side-effects
