| Description |
1 online resource (xv, 494 pages) : illustrations (chiefly color) |
| Contents |
Introduction. Historical perspective and current challenges of cancer genomics / Graham Dellaire and Robert J. Arceci -- Genomics technologies, concepts and resources. Second-generation sequencing for cancer genome analysis / Hye-Jung E. Chun, Jaswinder Khattra, Martin Krzywinski, Samuel A. Aparicio and Marco A. Marra -- Cancer transcriptome sequencing and analysis / Ryan D. Morin and Stephen B. Montgomery -- The significance of transcriptome sequencing in personalized cancer medicine / Shile Zhang, Jun S. Wei and Javed Khan -- Tissue microarrays in studying gynecological cancers / Cécile Le Page, Anne-Marie Mes-Masson and Anthony M. Magliocco -- Cancer pharmacogenomics in children / Shahrad Rod Rassekh and Colin J.D. Ross -- Biomarker discovery and development through genomics / Janet E. Dancey -- Preclinical animal models for cancer genomics / Jason N. Berman, Priscilla P.L. Chiu and Graham Dellaire -- Bioinformatics for cancer genomics / Katayoon Kasaian, Yvonne Y. Li and Steven J.M. Jones -- Genomic resource projects / Matthew Parker, Erin Hedlund and Jinghui Zhang -- Hereditary cancer syndromes. Genetic basis of hereditary cancer syndromes / David Malkin -- Genomics of adult and pediatric cancers. Adult solid tumors. Genomics and molecular profiling of lung cancer / Zhaolin Xu -- Breast cancer genomics / Moamen Bydoun, Paola Marcato and Graham Dellaire -- Prostate cancer genomics as a driver of personalized medicine / Michael Fraser, Alejandro Berlin, Veronique Ouellet, Fred Saad and Robert G. Bristow -- Genomics of colorectal cancer / Daniel Gaston and Carman Giacomantonio -- Thyroid cancer / Angela Greco, Claudia Miranda, Maria Grazia Borrello and Marco A. Pierotti -- Age non-specific tumors and hematopoietic malignancies. Acute myeloid leukemia / Robert J. Arceci, Jason N. Berman and Soheil Meshinchi -- Genomics in multiple myeloma: from conventional cytogenetics to novel whole genome sequencing approaches / Francesca Cottini, Kenneth C. Anderson, and Giovanni Tonon -- Brain tumor genomics: sequencing to clinical utility / Branavan Manoranjan, Parvez Vora, Chitra Venugopal and Sheila K. Singh -- Pediatric cancers. Genomic basis of pediatric lymphomas / Nathanael G. Bailey, Thomas Gross and Megan S. Lim -- Neuroblastoma / Daniel A. Morgenstern and Meredith S. Irwin -- Soft tissue sarcomas / Amal M. El-Naggar, Gabriel Leprivier and Poul H. Sorensen -- Wilms tumors / Elizabeth J. Perlman and Peter Hohenstein -- Ethics of genomics research. Cancer genomics and biobanking: exploring key ethical and legal issues / Matthew Herder, and Conrad V. Fernandez -- Future directions. The role of microRNAs and ultraconserved non-coding RNAs in cancer / Hui Ling and George A. Calin -- The impact of the environment on cancer genomics / Louise Parker |
| Summary |
Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from resource home page (ebrary, viewed October 6, 2015) |
| Subject |
Cancer -- Genetic aspects.
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Neoplasms -- genetics
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer -- Genetic aspects
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| Form |
Electronic book
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| Author |
Dellaire, Graham, 1971- editor.
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Berman, Jason N., editor
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Arceci, Robert, editor
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| ISBN |
9780123972743 |
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0123972744 |
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1306156874 |
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9781306156875 |
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0123969670 |
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9780123969675 |
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