| Description |
1 online resource |
| Contents |
Chemical introduction : sources, classification, and chemical properties of drugs -- Drug administration and distribution -- Drug elimination -- Elementary pharmacokinetics -- More complex and model independent pharmacokinetic models -- Kinetics of metabolism and excretion -- Further consideration of clearance, and physiological modelling -- Drug formulation : bioavailability, bioequivalence and controlled-release preparations -- Factors affecting plasma concentrations -- Pharmacogenetics and pharmacogenomics -- Developmental pharmacology and age-related phenomena -- Effects of disease on drug disposition -- Quantitative pharmacological relationships -- Simultaneous measurement of concentrations and effect, and pharmacokinetic/pharmacodynamic (PK/PD) modelling -- Drug monitoring in therapeutics -- Drug interactions -- Drug metabolism and pharmacokinetics in toxicology |
| Summary |
This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples. Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version |
| Subject |
Biopharmaceutics.
|
|
Drugs -- Metabolism.
|
|
Pharmacokinetics.
|
|
Biopharmaceutics.
|
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Pharmaceutical Preparations -- metabolism.
|
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Pharmacokinetics.
|
| Form |
Electronic book
|
| Author |
Whelpton, Robin.
|
|
Wiley InterScience (Online service)
|
| ISBN |
047066519X (electronic bk.) |
|
047066522X (electronic bk.) |
|
1119957419 (electronic bk.) |
|
9780470665190 (electronic bk.) |
|
9780470665220 (electronic bk.) |
|
9781119957416 (electronic bk.) |
|
