| Description |
1 online resource (x, 310 pages) : illustrations |
| Series |
Computational molecular biology |
|
Computational molecular biology.
|
| Contents |
Are the eyes homologous? -- Automation of protein sequence characterization and its application in whole proteome analysis -- Information fusion and metabolic network control -- Specificity of protein-DNA interactions -- Genomics of gene regulation: the view from Escherichia coli -- Discovery of DNA regulatory motifs -- Gene networks description and modeling in the GeneNet system -- Regulation of cellular states in mammalian cells from a genomewide view -- Predicting protein function and networks on a genomewide scale -- Metabolic pathways -- Toward computer simulation of the whole cell |
| Summary |
As exciting as the new field of genomics is, it has not yet produced a basic conceptual change in biology. The fundamental problems remain: the origin of life, cell organization, the pathways of differentiation, aging, and the molecular and cellular capabilities of the brain. What has occurred is an explosion of molecular information obtained by genomic sequences, which will soon be followed by exhaustive catalogs of protein interactions and protein function. This wealth of information can be analyzed and manipulated only with the help of computers. The rapidly expanding role of computers in biology may usher in a profound conceptual change in how we study living systems in the laboratory. This book focuses on current computational approaches to understanding the complex networks of metabolic and gene regulatory capabilities of the cell. The contributors look well beyond the state of the art in computational biology to anticipate what biological research will be like in a post-genomic world |
| Analysis |
BIOMEDICAL SCIENCES/Quantitative Biology |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Genetics -- Mathematical models.
|
|
Molecular biology -- Mathematical models
|
|
Genetic regulation.
|
|
Metabolism.
|
|
Models, Genetic
|
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Gene Expression Regulation
|
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Metabolism
|
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metabolism (biological concept)
|
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SCIENCE -- Life Sciences -- Molecular Biology.
|
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Metabolism
|
|
Genetic regulation
|
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Genetics -- Mathematical models
|
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Molecular biology -- Mathematical models
|
| Form |
Electronic book
|
| Author |
Collado-Vides, Julio
|
|
Hofestädt, Ralf
|
| ISBN |
9780262270649 |
|
0262270641 |
|
0585436916 |
|
9780585436913 |
|
9780262032971 |
|
026203297X |
|
