| Description |
1 online resource (785 p.) |
| Series |
New York Academy of Sciences Ser |
|
New York Academy of Sciences Ser
|
| Contents |
Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- SECTION 1 INTRODUCTION TO PHARMACOLOGY -- CHAPTER 1 ESSENTIAL LEXICON OF PHARMACOLOGY -- THE SOCIAL IMPACT OF PHARMACOLOGY -- ESSENTIAL LEXICON -- Active Substances -- Pharmacological Disciplines -- Drug-Receptor Interactions -- Measure of the Clinical Response -- TAKE-HOME MESSAGE -- CHAPTER 2 A SHORT HISTORY OF PHARMACOLOGY -- BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY -- From Magical and Natural Remedies of Ancient Medicine to Arabic Alchemy -- From Monastic Medicine to Botanical Gardens |
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From Anatomical Renaissance to the "Experienz": Paracelsus' Spagyric -- From Iatrochemistry to the Age of Enlightenment -- From the Search of the Active Principle to the Discovery of Alkaloids and Glucosides -- The Drug Synthesis Revolution: From Handmade to Industrial Production -- MODERN PHARMACOLOGY -- Ehrlich and Chemotherapy: The Concept of Receptor -- The Birth of Modern Pharmacology -- THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM -- The Impact of New Biotechnologies: Molecular Biology, Bioinformatics, and Combinatorial Chemistry |
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Biological Drugs and Pharmacology Perspectives -- Personalized Therapies and New Sceneries in Pharmaceutical Industry -- TAKE-HOME MESSAGE -- FURTHER READING -- SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION -- CHAPTER 3 CELLULAR BASIS OF PHARMACOKINETICS -- A QUICK JOURNEY WITH THE DRUG IN THE BODY -- Absorption -- Distribution -- Drug Elimination -- CROSSING CELL MEMBRANES -- Passive Diffusion across Cell Membranes -- Drug Transport across Cell Membranes -- Endocytosis -- DRUG DIFFUSION TO ORGANS AND TISSUES -- Properties of the Most Important Cell Barriers -- TAKE-HOME MESSAGE |
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FURTHER READING -- CHAPTER 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES -- GENERAL RULES ABOUT DRUG ABSORPTION RATE -- Partition Coefficient -- Drug Dispersion -- Extension of the Absorbing Surface -- Permeability of the Absorbing Surface -- Vascularization -- ENTERAL ROUTES OF ADMINISTRATION -- Oral Route -- Sublingual and Rectal Routes -- SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION -- The Intravascular Route -- i.m. Injection -- Subcutaneous and Intradermal Injections -- OTHER ROUTES OF DRUG ADMINISTRATION -- Inhalation Route -- Topical/Regional Routes -- Intracavity Routes |
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Dermal or Transcutaneous Route -- Mucosal Routes -- ABSORPTION KINETICS -- General Rules -- Interrelation between Gene Therapy and Drug Delivery Techniques -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 5 DRUG DISTRIBUTION AND ELIMINATION -- DISTRIBUTION -- Tissues and Avidity for Drugs -- The Apparent Distribution Volume -- Drug Binding to Plasma Proteins -- Factors That Determine the Distribution Rate of Drugs to the Various Compartments -- ELIMINATION -- The Concept of Half-Life -- The Concept of Clearance -- RENAL EXCRETION OF DRUGS -- Glomerular Filtration |
| Notes |
Description based upon print version of record |
|
Tubular Functions and Pharmacokinetics |
| Genre/Form |
Electronic books
|
| Form |
Electronic book
|
| ISBN |
9781118768594 |
|
1118768590 |
|
