| Description |
1 online resource (xvi, 438 pages) |
| Series |
Chapman & Hall/CRC biostatistics series |
|
Chapman & Hall/CRC biostatistics series
|
| Contents |
1. What is a non-inferiority trial? -- 2. Non-inferiority trial considerations -- 3. Strength of evidence and reproducibility -- 4. Evaluating the active control effect -- 5. Across-trials analysis methods -- 6. Three-arm non-inferiority trials -- 7. Multiple comparisons -- 8. Missing data and analysis sets -- 9. Safety studies -- 10. Additional topics -- 11. Inference on proportions -- 12. Inferences on means and medians -- 13. Inference on time-to-event endpoints |
| Summary |
"The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Using examples from real clinical trials, the book discusses general and regulatory issues and illustrates how they affect analysis. Each chapter begins with a non-technical introduction, so the subject is easily understood by those without prior knowledge of non-inferiority clinical trials. The book also provides detailed mathematical approaches along with their mathematical properties"--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Drugs -- Testing.
|
|
Experimental design.
|
|
Therapeutics, Experimental.
|
|
Clinical Trials as Topic
|
|
Research Design
|
|
Therapies, Investigational
|
|
MEDICAL -- Chemotherapy.
|
|
Drugs -- Testing
|
|
Experimental design
|
|
Therapeutics, Experimental
|
| Form |
Electronic book
|
| Author |
Wiens, Brian L.
|
|
Chan, Ivan S. F.
|
| ISBN |
9781584888055 |
|
1584888059 |
|
