| Description |
1 online resource (1 volume) : illustrations (black and white, and color) |
| Contents |
Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities |
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2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy |
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3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP |
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4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References -- Chapter 5: The role of inflammaging in the development of chronic diseases of older people -- 5.1. Introduction -- 5.2. Basic mechanisms: Cellular senescence, inflammaging, molecular inflammation, and senoinflammation -- 5.2.1. Cellular senescence -- 5.2.2. Inflammaging -- 5.2.3. Molecular inflammation -- 5.2.4. Senoinflammation -- 5.3. Is chronic inflammatory state a common denominator of ARDs? -- 5.3.1. T2DM |
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5.3.2. Chronic aging-related respiratory diseases -- 5.3.3. Atherosclerosis -- 5.3.4. Frailty -- 5.3.5. Alzheimer's disease (AD) -- 5.3.6. Parkinson's disease (PD) -- 5.4. The case of COVID-19 -- 5.5. Proposed interventions to prevent ARDs -- 5.6. Conclusion and future perspective -- References -- Chapter 6: A new perspective on ROS in aging with an integrated view of the gut microbiota -- 6.1. Introduction -- 6.2. The reactive oxygen species -- 6.3. The biological function of ROS -- 6.4. The oxidative stress theory of aging |
| Notes |
Includes index |
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Print version record |
| Subject |
Aging.
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Age factors in disease.
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Aging
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Age Factors
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Age factors in disease
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Aging
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| Form |
Electronic book
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| Author |
Carudo, Calogero, editor
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Candore, Giuseppina, editor
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| ISBN |
9780128227374 |
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0128227370 |
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