| Description |
1 online resource (xi, 352 pages) : illustrations |
| Contents |
A personal history of the development of the apoptosis concept / John F.R. Kerr -- What do the clinical data tell us about the role of apoptosis in sensitivity to cancer therapy? / George D. Wilson -- Response of solid tumors to cancer therapy : how relevant is apoptosis? / J. Martin Brown -- Historical studies of various forms of programmed cell death / Richard A. Lockshin and Zahra Zakeri -- Toward a mechanistic taxonomy for programmed cell death pathways / Dale E. Bredesen -- Caspase-independent apoptotic cell death / Lotti Egger -- Autophagic cell death in mammalian cells / David T. Madden -- The cellular decision between apoptosis and autophagy / Yongjun Fan, Erica Ullman, and Wei-Xing Zong -- Parthanatos : PARP and AIF-dependant programmed cell death / Valina L. Dawson and Ted M. Dawson -- Paraptosis / Sabina Sperandio and Ian de Belle -- Cellular senescence and its effects on carcinogenesis / Judith Campisi -- Tumor-suppressing activities of senescent keratinocytes / Brian J. Nickoloff -- Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells / Daniel DiMaio [and others] -- Treatment-induced tumor cell senescence and its consequences / Igor B. Roninson and Eugenia V. Broude -- Senescence regulation in cancer therapy / Abdelhadi Rebbaa -- Exploiting drug-induced senescence in trasgenic mouse models / Mehtap Kilic and Clemens A. Schmitt -- Therapy-induced cellular senescnece : clinical relevance, implications, and applications / Daniel Y. Wu [and others] -- Mitotic catastrophe in cancer therapy / Eugenia V. Broude [and others] -- How do cells die after irradiation? Time-lapse studies of cells in culture / William C. Dewey -- Modes of cell death by anticancer agents : the crucial importance of dose / J. Martin Brown |
| Summary |
Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to examine alternative mechanisms for the anti-proliferative action of anticancer agents, as well as moving forward in the complete eradication of cancer. The goal of Beyond Apoptosis: Cellu |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cancer -- Chemotherapy.
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Apoptosis.
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Oncology.
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Antimitotic agents.
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Antineoplastic agents.
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Neoplasms -- drug therapy
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Medical Oncology
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Apoptosis
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Antimitotic Agents
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Antineoplastic Agents
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Apoptosis -- drug effects
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Cellular Senescence -- drug effects
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Mitosis -- drug effects
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Oncology
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Antineoplastic agents
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Antimitotic agents
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Apoptosis
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Cancer -- Chemotherapy
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| Form |
Electronic book
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| Author |
Roninson, Igor B.
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Brown, J. M. (J. Martin)
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Bredesen, Dale E.
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| ISBN |
9781420020502 |
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1420020501 |
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9786611801250 |
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6611801251 |
|
