| Description |
1 online resource (343 p.) |
| Series |
New York Academy of Sciences Ser |
|
New York Academy of Sciences Ser
|
| Contents |
Human Biological Aging: From Macromolecules to Organ Systems -- Contents -- Preface -- About the Companion Website -- Section 1: The Foundation -- Essential Preparatory Material -- Chapter 1: Orientation -- Beginnings of Biogerontology -- Multiple Disciplines Come Together to Study Biological Aging -- Population Aging -- Dramatic Increase in Life Expectancy Due to Public Health Advancements: Sanitation, Clean Water, Vaccines, and Antibiotics -- Does Living Longer Assure Living Healthier? -- Characteristics of Aging |
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The Fundamentals of Physics Describe Aging as the Loss of "Molecular Fidelity" That Exceeds Repair and Replacement -- The Commencement of Aging Is Debated -- Rates of Aging Among Different Species May Be Rapid, Gradual, or Negligible -- The Senescence Phenotype Is Highly Variable -- Components of Longevity -- Longevity Is in Part Heritable Through Expression of Longevity Determinants: Mechanisms of Maintenance, Repair, and Replacement -- Longevity of the Centenarians and Supercentenarians Reveals Few Common Threads -- Stochastic Events Exert Major Impact on Lifespan -- Theories of Aging Overview |
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Randomized Controlled Trials and Meta-Analysis are Additional Formats for the Study of Aging in Man -- Caloric Restriction: Life Extension Experiment -- Physiological Changes with Caloric Restriction -- CR in Man is Underway -- Mechanisms of Caloric Restriction -- CR is Analogous to Food Shortage in the "Wild" -- Caloric Restriction as an Example of Hormesis -- Laboratory Animal Models -- Animal Models Are Useful Adjuncts to the Study of the Aging Process -- Yeast: Saccharomyces cerevisiae -- Roundworm: Caenorhabditis elegans -- Fruit fly: Drosophila melanogaster -- Mouse: Mus musculus |
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Nonhuman Primate: Macaca mulatta -- Man As Model: Baltimore Longitudinal Study -- Progeroid Syndromes as Premature Aging -- Summary -- Critical Thinking -- Key Terms -- Bibliography -- Chapter 3: Evolutionary Theories of Aging -- Historical Views and Insights -- Unsupportable Programmed Aging Is Replaced by Evolutionary Tenets -- Darwin's Evolutionary Tenets -- Natural Selection Favors Survival Traits -- Genes and Evolution -- Genes (DNA Sequences) Possess the Hereditary Information That Is Passed from Generation to Generation through the Germline (Gametes) |
| Summary |
Critical Thinking -- Key Terms -- Bibliography -- Chapter 2: Measurements and Models -- The Scientific Method -- Types of Data -- Not All Data are of Equal Value -- Issues with Aging Studies in Man -- Studies of Human Aging Encounter Difficulties: Heterogeneity, Organizational Level, and Others -- Aging Assessed from Demographic or Individual Perspective -- Measurement of the Aging Process -- Study Designs Are Mainly Cross-Sectional and Longitudinal -- Cross-Sectional Study Design Infers Aging -- Longitudinal Study Design Measures Aging Directly |
| Notes |
Description based upon print version of record |
|
Evolved Traits Arise through Genetic Variations |
| Genre/Form |
Electronic books
|
| Form |
Electronic book
|
| ISBN |
9781118967034 |
|
1118967038 |
|
