| Description |
1 online resource (321 pages) |
| Series |
Masterclass in Neuroendocrinology ; v. 11 |
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Masterclass in neuroendocrinology series ; v. 11.
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| Contents |
Intro -- Series Preface -- Volume Preface -- Contents -- Part I: Glial-Neuronal Interactions in the Control of Hypothalamic Development -- 1: The Role of Microglia in the Developing Hypothalamus -- 1.1 Introduction -- 1.1.1 Hypothalamic Organization and Function in the Neuroendocrine System -- 1.1.2 Microglia Invasion During Hypothalamic Development -- 1.1.3 Hypothalamic Gliogenesis -- 1.2 Unraveling Hematopoiesis and the Unique Origins of Microglia -- 1.2.1 Hematopoiesis -- 1.2.2 Microglial Origins -- 1.2.3 Border-Associated Macrophages |
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1.3 Local Environmental Signals Shape Microglia Development and Influence Microglial Heterogeneity -- 1.3.1 Microglial Heterogeneity -- Box 1.1: Single-Cell RNA Sequencing -- 1.4 Microglial Functions During Hypothalamic Development -- 1.4.1 Importance of Embryonic Microglia for the Proper Development of Hypothalamic Circuitry -- Box 1.2: Using CSF1R Inhibitors to Deplete Microglia in the CNS -- Box 1.3: Hypothalamic Circuitry Involved in Feeding and Energy Balance -- 1.5 Microglia Are Sexually Dimorphic and Contribute to Sexual Dimorphism Within the Hypothalamus |
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1.5.1 A Role for Microglia in the Establishment of Sexually Dimorphic Brain Regions -- 1.6 Embryonic Microglia Act as Sensors During Development -- 1.7 Perspectives -- 1.8 Key Literature -- References -- Part II: Glial-Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System -- 2: Functional Consequences of Morphological Plasticity in the Adult Hypothalamo-Neurohypophysial System -- 2.1 Introduction: Structural Glial Plasticity in the Adult HNS -- 2.1.1 Anatomy of the HNS System -- 2.1.2 Functions of Oxytocin and Vasopressin |
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2.1.3 Electrophysiology of Oxytocin and Vasopressin Neurons -- 2.1.4 Glial Cells of the HNS -- 2.1.5 Structural Glial Plasticity in the Adult HNS -- 2.1.6 Investigating the Functional Consequences of Structural Plasticity -- 2.2 Contribution of the Astrocytic Environment to Homosynaptic Strength -- Box 2.1: Investigating the Presynaptic Origin of Drug Action Using Paired-Pulse Facilitation -- 2.2.1 Role of Glutamate Uptake on Homosynaptic Efficacy -- 2.2.2 Control of Homosynaptic Efficacy Through Metabotropic Glutamate Receptors -- 2.2.3 Glial Coverage Controls Homosynaptic Efficacy |
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2.2.4 Glial Coverage Controls Concentration and/or Time Course in the Synaptic Cleft -- 2.2.5 Physiological Consequences -- 2.3 Contribution of the Astrocytic Environment to Inter-synaptic Crosstalk -- 2.3.1 Glial Coverage Controls Diffusion in the Extracellular Space -- 2.3.2 Changes in Diffusion Facilitate Heterosynaptic Activity Through Metabotropic Glutamate Receptors -- 2.3.3 Limiting Changes in Diffusion Affect Glutamate Spillover -- 2.3.4 Functional Presynaptic Kainate Receptors on GABAergic Terminals in the HNS |
| Summary |
This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology |
| Notes |
2.3.5 Changes in Glial Coverage Switches Kainate Receptor Presynaptic Action |
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Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Neuroglia.
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Neuroendocrinology.
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Neuroglia
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Neuroendocrinology
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Neuroendocrinology
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Neuroglia
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Neuròglia.
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Neuroendocrinologia.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Tasker, Jeffrey G.
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Bains, Jaideep S
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Chowen, Julie A.
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| ISBN |
9783030623838 |
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3030623831 |
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