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Title Crohn's disease and ulcerative colitis : from epidemiology and immunobiology to a rational diagnostic and therapeutic approach / Daniel C. Baumgart, editor
Edition Second edition
Published Cham, Switzerland : Springer, 2017
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Description 1 online resource (xx, 695 pages) : illustrations
Contents Foreword; Preface to the Second Edition; Preface; Contents; Contributors; Part I: Epidemiology; 1: Environmental Factors in€the€Epidemiology of€Inflammatory Bowel Disease; Introduction; Geography; Variation Between Countries; Variations Within€European Countries: Population-Based Studies (Fig.€1.7); Relationship Between UC and€CD; Environmental Factors; Relationship to€Microbiology; Relationship Between€Environment and€Geography; Socioeconomic Factors; Smoking; Nutrition and€Diet; Microparticles and€Pollution; Nonsteroidal Anti-inflammatory Drugs; Oral Contraceptives
Effects of€Genes Versus the€Environment How Decisive Are Commensal Bacteria?; Loss of€Intestinal Immune Homeostasis in€IBD; Alterations of€Mucosal IgA and€Epithelial Barrier Function; Antibodies to€Commensals and€Abrogated Tolerance; Conclusions; References; 3: Understanding the€Epithelial Barrier in€IBD; The Epithelial Barrier Is Regulated in€Response to€Physiologic Stimuli; The Intestinal Barrier Is Compromised in€IBD; The Epithelial Monolayer; Molecular Anatomy of€the€Tight Junction; Intercellular Junctions and€IBD; Barrier Defects and€Mucosal Immune Regulation
Formation and€Properties of€Secretory Antibodies The Epithelial Barrier Function; Additional IgA Antibody Functions; Effect of€Microbial-Host Interactions on€Innate and€Adaptive Immunity; The Epithelial Barrier and€Secretory Immunity; The Role of€Mucus in€Intestinal Barrier Function; Interactions of€SIgA with€Commensal Bacteria; Role of€IgA and€Breastfeeding in€Immune Control; Mucosal Homeostasis Versus€Hypersensitivity; Oral Tolerance in€Humans; Mucosal Tolerance Induction; Recognition of€Microbial Components; Innate Signals Dictating Homeostasis
Isolated Barrier Defects Are Insufficient to€Cause Disease A Multifactorial Model of€IBD; Barrier Restoration as€a€Future Therapeutic Intervention; References; 4: Intestinal Microbiology and€Ecology in€Crohn's Disease and€Ulcerative Colitis; Structure and€Functionality of€the€Intestinal Microbiota; Factors Influencing the€Intestinal Microbiota Composition; The Role of€the€Intestinal Microbiota in€IBD; Intestinal Microbiota Composition in IBD; Genetic Background Contribution in€IBD; Intestinal Microbiota-Immune System Interaction in€IBD
Seasonal Variability Appendectomy and€Tonsillectomy; General Remarks and€Future Aspects Regarding€Global Environmental Risk Factors in€IBD; References; Part II: Immunobiology; 2: Role of€the€Intestinal Immune System in€Health; Introduction; Induction and€Regulation of€Intestinal Immunity; Mechanisms Promoting Homeostasis; Inductive Gut-Associated Lymphoid Tissue Structures; Activation and€Homing of€Intestinal B Cells; Regional Intestinal Immune Differences; Intestinal Immunity in Infancy; Secretory Immunity and€the€Epithelial Barrier Function
Summary This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohnℓ́ℓs Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohnℓ́ℓs disease, ulcerative colitis, and related autoimmune disorders
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed March 14, 2017)
Subject Crohn's disease.
Crohn Disease.
Colitis, Ulcerative.
Form Electronic book
Author Baumgart, Daniel, editor
LC no. 2016959449
ISBN 3319337033 (electronic bk.)
9783319337036 (electronic bk.)
(print)