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Book Cover
E-book
Author Aldridge, W. Norman

Title Mechanisms and concepts in toxicology / W. Norman Aldridge
Published London, UK ; Bristol, PA, USA : Taylor & Francis, ©1996

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Description 1 online resource (xi, 254 pages) : illustrations
Contents Chapter 1 Scope of Toxicology -- chapter 2 Stages in the Induction of Toxicity -- chapter 3 Kinetics and End-points -- chapter 4 Acute and Chronic Intoxication -- chapter 5 Delivery of Intoxicant: Decrease in delivery to the target -- chapter 6 Delivery of Intoxicant: Bioactivation and increase in delivery to the target -- chapter 6 2 Bioactivation -- chapter 6 4 Cytochrome P450s -- chapter 6 5 Active Transport of Intoxicants -- chapter 6 6 Biliary Excretion and Enterohepatic Circulation -- chapter 6 8 Discussion -- chapter 6 9 Summary -- chapter 7 Initiating Reactions with Targets -- chapter 8 Biological Consequences of Initiating Reactions with Targets -- chapter 9 Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds -- chapter 10 Selective Toxicity, Animal Experimentation and In Vitro Methods -- chapter 11 Biomonitoring -- chapter 12 Epidemiology -- chapter 13 Environmental and Ecotoxicology -- chapter 14 Reflections, Research and Risk
Summary This text focuses on research procedures in toxicology, aiming to illustrate toxicological concepts and types of toxicity from a mechanistic point of view. Mechanistic research in toxicology leads not only to a greater understanding of the biology involved, but also the means to design substances with selectivity between species and minimal undesirable side effects. Examples of chemical intoxicants are used to illustrate mechanisms in each stage of developing toxicity
Analysis Toxicology
Bibliography Includes bibliographical references (pages 218-247) and index
Notes Print version record
Subject Toxicology.
Toxicology
toxicology.
MEDICAL -- Toxicology.
Toxicology
Toxicologie.
Toxicologie.
Toxicologia.
Form Electronic book
ISBN 0203290283
9780203290286
9780203211212
0203211219
9780429217920
0429217927