| Description |
1 online resource (351 pages) |
| Series |
Respiratory Disease Series: Diagnostic Tools and Disease Managements |
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Respiratory disease series.
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| Contents |
Preface; References; Contents; Part I: Definition and Epidemiology; Chapter 1: Definition of Chronic Obstructive Pulmonary Disease (COPD): Is the Latest GOLD Classification of Severity Still Val ... ; 1.1 Introduction; 1.2 Historical Transition of the Concept of COPD; 1.3 Difference Between COPD and Bronchial Asthma; 1.4 Chronic Bronchitis and Pulmonary Emphysema; 1.5 Global Initiative for Chronic Obstructive Lung Disease (GOLD); 1.6 Combined COPD Assessment; 1.7 Conclusion; References; Chapter 2: Epidemiology of COPD: Why Is the Disease So Poorly Recognized?; 2.1 Introduction |
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2.2 Risk Factors of COPD2.2.1 Cigarette Smoking; 2.2.2 Other Risk Factors; 2.2.2.1 Genetic Factors; 2.2.2.2 Environmental Factors; Occupational Airborne Particles; Air Pollution; Indoor Air Pollutants; Outdoor Air Pollution; 2.2.2.3 Low Socioeconomic Status; 2.3 Decline in FEV1 in Patients with COPD; 2.4 Incidence of COPD; 2.5 Prevalence of COPD; 2.6 Undiagnosed COPD; 2.7 Impact of COPD on Health Status in the General Population; 2.8 Conclusions; References; Part II: Genetic Predisposition and Pathogenic Mechanisms |
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Chapter 3: Genetic Predisposition to COPD: Are There Any Relevant Genes Determining the Susceptibility to Smoking?3.1 Introduction; 3.2 Investigation of the Genes Related to COPD Pathogenesis: The Era Before GWAS; 3.3 Genome-Wide Association Studies (GWASs) for Susceptibility Genes of COPD; 3.4 Recent Progress of Studies of COPD Genetics in GWAS Era (I): Relevant Genes Determining the Susceptibility to Smoking; 3.5 Recent Progress of Studies of COPD Genetics in GWAS Era (II): Gene Related to Critical Subtypes or Phenotypes of COPD |
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3.6 Recent Progress of Studies of COPD Genetics in GWAS Era (III): Novel Strategy for Research on COPD Genetics with Multi-omi ... 3.7 Recent Progress of Studies of COPD Genetics in GWAS Era (IV): Next-Generation Sequencing and Arrays; 3.8 Recent Progress of Studies of COPD Genetics in GWAS Era (V): Pharmacogenetics and Pharmacogenomics in COPD; 3.9 Conclusions; References; Chapter 4: Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of ... ; 4.1 Introduction; 4.2 Airway Inflammation and Changes in COPD |
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4.2.1 Airway Structure and Mucus Production in Patients with COPD4.2.2 Lung Destruction in COPD; 4.2.3 Inflammatory Cells and Cytokines in the Airway in COPD; 4.3 Airway Inflammation After Smoking Cessation; 4.3.1 Innate Immune System; 4.3.1.1 The Role of TLRs; 4.3.1.2 The Role of NLRs; 4.3.1.3 The Role of RLRs; 4.3.1.4 The Role of RAGE; 4.3.2 Adaptive Immune System; 4.3.2.1 The Role of B Cells; 4.3.2.2 The Role of T Cells; 4.3.3 COPD Deterioration After Smoking Cessation; 4.3.3.1 COPD Deterioration by COPD Itself; 4.3.3.2 COPD Deterioration by Latent Respiratory Infection |
| Summary |
This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future. Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD |
| Notes |
4.3.3.3 COPD Deterioration by Exacerbation |
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Print version record |
| Subject |
Lungs -- Diseases, Obstructive.
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Pulmonary Disease, Chronic Obstructive
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Lungs -- Diseases, Obstructive
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| Form |
Electronic book
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| Author |
Nakamura, Hiroyuki
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Aoshiba, Kazutetsu
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| ISBN |
9789811008399 |
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9811008396 |
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