| Description |
1 online resource (412 p.) |
| Contents |
880-01 Intro -- Preface -- Contents -- Editors and Contributors -- Part I: Hypoxic, High-Altitude, and Extreme Stress: Health Implications and Interventions -- 1: Stress and Adaptogens -- 1.1 Introduction -- 1.2 Classification of Stress -- 1.3 What Are Adaptogens? -- 1.4 Possible Mechanism of Adaptogens in Stress Management -- 1.5 Role of Adaptogens: Few Examples -- 1.5.1 Rhodiola imbricata -- 1.5.2 Hippophae rhamnoides -- 1.5.3 Ganoderma lucidum -- 1.5.4 Cordyceps sinensis -- 1.6 Conclusion -- References -- 2: Molecular Basis of Response to Hypoxia -- 2.1 Introduction |
|
880-01/(S 5.2 Role of VEGF in Maintaining Skeletal Muscle Capillarity -- 5.3 Role of VEGF in Retina and Brain Angiogenesis -- 5.4 Role of Hypoxia Responsive Genes -- HIF1-α and VEGF in Sickle Cell Anemia -- 5.5 Concluding Remarks -- References -- 6: Thrombogenetic Risk at High Altitude: Early Diagnosis and Treatment Modalities -- 6.1 Introduction -- 6.1.1 Epidemiology of Venous Thromboembolism (VTE) -- 6.1.2 Risk Factors -- 6.1.2.1 Acquired -- 6.1.2.2 Inherited/Genetic Risk Factors -- 6.1.3 Environmental Conditions at High Altitudes (HA) -- 6.2 Risk of Recurrent Thrombosis |
|
2.2 Hypoxia-Inducible Factor (HIF) -- 2.2.1 Isoforms and Domain Organization -- 2.2.2 HIF Regulation -- 2.2.2.1 Post-Translational Modification -- 2.2.2.2 Epigenetic Regulation -- 2.2.3 Oxygen-Independent Regulation -- 2.2.4 HIF Signaling -- 2.3 Adaptations -- 2.3.1 Metabolic -- 2.3.2 Angiogenesis -- 2.4 Conclusion -- References -- 3: Hypoxia-Inducible Factor Activation in High-Altitude Stress -- 3.1 Introduction -- 3.2 HIF-1 Domain Structure -- 3.3 Role of Hypoxia-Inducible Factor 1 in Various Organs -- 3.3.1 HIF-1 Mediated Angiogenesis in Cardio Protection |
|
3.3.2 Adverse Role of HIF-1 Activation in Myocardium -- 3.3.3 HIF-1 Action in Hypoxic Lung Injury -- 3.3.4 Transcriptional Activity in Kidney -- 3.3.5 Erythropoietic Action of HIF-1 in Brain -- References -- 4: Regulation of Vascular Endothelial Growth Factor by SUMOylation in Hypoxic Cardiomyocytes -- 4.1 Introduction -- 4.1.1 Oxygen (O2): A Fundamental Element of Human Body -- 4.2 Lack of Oxygen: Hypoxia -- 4.3 General Cardiovascular Responses to Hypoxia -- 4.3.1 Vascular Endothelial Growth Factor -- 4.3.2 Cardiomyocytes as a Producer and Target of VEGF-A |
|
4.3.3 Mechanisms Involved in the Regulation of VEGF-A Functions -- 4.3.3.1 Upregulation Mechanisms of VEGF-A -- 4.3.3.2 Downregulation Mechanisms of VEGF-A -- 4.4 SUMOylation: A Posttranslational Protein Modification -- 4.4.1 The Family of SUMO Proteins -- 4.4.2 SUMOylation in Response to Hypoxia -- 4.4.3 SUMOylation in Cardiovascular Diseases -- 4.5 VEGF Regulation by SUMOylation During Hypoxic Stress -- References -- 5: Expression of Vascular Endothelial Growth Factor at High Altitude -- 5.1 Introduction -- 5.1.1 Hypoxemia -- 5.1.2 Oxygen Delivery -- 5.1.3 Oxygen Extraction or Utilization |
| Summary |
The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resiliencea state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibrated through pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges |
| Notes |
6.3 Early Symptoms and Diagnosis of VTE |
|
Online resource; title from PDF title page (SpringerLink, viewed January 29, 2024) |
| Subject |
Adaptation (Physiology)
|
| Form |
Electronic book
|
| Author |
Tulsawani, Rajkumar
|
|
Vohora, Divya
|
| ISBN |
9789819976522 |
|
9819976529 |
|
