| Description |
1 online resource |
| Contents |
Anti-Angiogenic Cancer Therapy: Development of Resistance / Domenico Ribatti -- Anti-angiogenic Targeting in Metastatic Colorectal Cancer Therapy / Thomas Zander, Valentin Goede, Michael Hallek -- Anti-angiogenic Targets: Angiopoietin and Angiopoietin-Receptors / Elina A. Kiss, Pipsa Saharinen -- Anti-angiogenics and Radiation Therapy / Daniel H. Schanne, Anca-L. Grosu, Dan G. Duda -- Anti-Angiogenics in Gastroesophageal Cancer / Ulrich Hacker, Florian Lordick -- Anti-angiogenics in Hepatocellular Cancer Therapy / Martha M. Kirstein, Arndt Vogel -- Anti-Angiogenics in Pancreatic Cancer Therapy / Thilo Hackert, Laura Wüsten, Markus W. Büchler -- Benefits and Pitfalls of Tumor Vessel Normalization / Jin-Sung Park, Intae Park, Gou Young Koh -- Biomarkers for Anti-angiogenic Therapy / Weibin Hou, Stefan Duensing -- Combination of Antiangiogenics and Other Targeted Therapies / Katja Zirlik, Justus Duyster -- Controlling Vascular Permeability: How Does It Work and What Is the Impact on Normal and Pathological Angiogenesis / Inga Bekes, Christine Wulff -- Cytotoxics and Anti-Angiogenics: Metronomic Therapies / Andreas Pircher, Normann Steiner, Eberhard Gunsilius -- Endothelial Cell-Cell Junctions in Tumor Angiogenesis / Quentin Roux, Julie Gavard -- Imaging Tumor Angiogenesis / Gordon Jayson, James O'Connor -- Inhibition of Tumor Angiogenesis in GIST Therapy / Charlotte Benson, Michela Libertini -- Inhibition of Tumor Angiogenesis in the Treatment of Lung Cancer / Massimo Di Maio, Silvia Novello, Enrica Capelletto, Giorgio Vittorio Scagliotti -- Mechanisms of Anti-Angiogenic Therapy / Roser Pons-Cursach, Oriol Casanovas -- Mechanisms of Tumor Angiogenesis / Iratxe Zuazo-Gaztelu, Oriol Casanovas -- Pathology of Tumor Angiogenesis / Peter Bronsert, Martin Werner -- The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis / Melanie Hofmann, Joerg Heineke -- The Implication of Antiangiogenic Treatment of Malignancies on Human Metabolism / Nina Obad, Rolf Bjerkvig -- The Role of VEGF in Controlling Vascular Permeability / Lakshmi Venkatraman, Lena Claesson-Welsh -- The Value of Anti-angiogenics in Bladder Cancer Therapy / Gerald Bastian Schulz, Alexander Karl -- The Value of Anti-angiogenics in Cervical Cancer Therapy / Thalia Erbes, Juliane Farthmann, Kai Berner -- The Value of Anti-angiogenics in Head and Neck Cancer Therapy / Valérie Cristina, Sandrine Faivre -- The Value of Anti-Angiogenics in Multiple Myeloma Therapy / Thomas Moehler, Dirk Hose, Mindaugas Andrulis, Anja Seckinger, Hartmut Goldschmidt -- The Value of Anti-angiogenics in Ovarian Cancer Therapy / Sven Mahner, Fabian Trillsch -- The Value of Anti-angiogenics in Primary Brain Tumor Therapy / E. Schorb, C. F. Waller -- The Value of Anti-angiogenics in Prostate Cancer Therapy / Krisztian Homicsko, Dominik Berthold -- The Value of Anti-Angiogenics in Soft Tissue Sarcoma Therapy / Bernd Kasper, Charlotte Benson -- The Value of Antiangiogenics in Breast Cancer Therapy / Malgorzata Banys-Paluchowski, Tanja Fehm, Volkmar Müller |
| Summary |
"Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented."--Publisher's website |
| Bibliography |
Includes bibliographical references |
| Notes |
Description based on online resource (viewed January 22, 2019) |
| Subject |
Tumors -- Blood-vessels -- Growth
|
| Form |
Electronic book
|
| Author |
Marmé, D. (Dieter) editor
|
| ISBN |
3319312154 |
|
9783319312156 |
|
