Title TRIPS across epithelial and endothelial barriers in health and disease / Alexander V. Zholos, Ganna M. Tolstanova, editors

Published New York : Nova Science Publishers, [2021]

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Description 1 online resource Series Cell Biology Research Progress Ser Cell Biology Research Progress Ser Contents Intro -- Contents -- Preface -- Introduction to Various Barriers Existing in the Human Body and the Role of TRP Channels -- References -- Section I. Regulation of a Barriers' Integrity is About Team-Play of Different Molecules -- Chapter 1 -- Overview of TRP Channels -- Abstract -- Introduction -- Mammalian TRP Channels -- Molecular and Functional Interactions of TRP Channels with Molecular Components of Cell-Cell Junctions -- Acknowledgments -- References -- Chapter 2 -- Calcium-Dependent Regulation of Barriers' Integrity with Focus on TRP Channels -- Abstract -- Introduction TRP Channels and Calcium Signaling -- TRP Channels and Barrier's Integrity -- TRPC4, TRPM3 and TRPM7 -- TRPV1 -- TRPV4 -- TRPA1 -- Conclusion -- Acknowledgments -- References -- Chapter 3 -- Inflammation and Its Mediators -- Abstract -- Introduction -- Inflammatory Mediators and Vascular Permeability Mechanisms -- Chronic Inflammation: Focus on Macrophages -- TRP Channels and Inflammatory Response -- Canonical (TRPC) Subfamily -- Vanilloid (TRPV) Subfamily -- Melastatin (TRPM) Subfamily -- Ankyrin (TRPA) Subfamily -- Conclusion -- Acknowledgments -- References -- Chapter 4 Gut Microbiota and Gap/Tight Junctions -- Abstract -- Introduction -- Regulation of a Barrier's Integrity Is About Team-Play of Gut Microbiota -- Diet and Intestinal Mucus Affect Microbiota Composition -- Immune System Affects Microbiota Composition -- Communication Strategy of Microbiota -- Conclusion -- Regulation of a Barrier's Integrity Is About Team-Play of Different Molecules: Gap/Tight Junctions -- Conclusion -- References -- Section II. Epithelial Barriers -- Chapter 5 -- Role of TRP Channels and Calcium Signalling in Skin and Airways -- Abstract -- Introduction TRP Channels in Health and Disease of the Skin -- TRP Channels Found in Airways and Their Roles in Respiratory Diseases -- Acknowledgments -- References -- Chapter 6 -- Versatile Gut Barrier: One Barrier -- Many Diseases -- Abstract -- Introduction -- Intestinal Mucosal Barrier: Focus on Short Chain Fatty Acids -- TRP Channels Are Candidate Fatty Acid Sensors -- Conclusion -- Intestinal Mucosal Barrier Function in Irritable Bowel Syndrome -- Intestinal Mucosal Barrier Function in Inflammatory Bowel Diseases -- Conclusion -- Intestinal Epithelial Barrier Function in Urinary Tract Diseases Intestinal Barrier and Recurrent Urinary Tract Infections -- Intestinal Barrier and Chronic Kidney Disease -- Intestinal Barrier and Oxalate Homeostasis in Chronic Kidney Disease -- Conclusion -- Acknowledgments -- References -- Chapter 7 -- The Exquisite Sensitivity of the Uterine Epithelium: Pregnant vs. Non-Pregnant Status of the Endometrium -- Abstract -- Introduction -- Expression of TRP Channels in the Endometrium -- TRP Channels in Functioning of the Endometrium -- TRP Channels in Pathogenesis of the Reproductive Abnormalities -- Conclusion -- References -- Chapter 8 Summary "Life on Earth began some 4 billion years ago when the first primitive prokaryotes managed to isolate themselves from the rather hostile environment. The immediate challenge that these first life forms faced was to ensure an optimal balance between two apparently mutually exclusive tasks - protection and separation from the extracellular milieu on the one hand and an efficient exchange of ions, energy sources and metabolites with the very same milieu on the other hand. The commencing evolutionary progress had to address even more challenging problems, such as how to delegate specific cell functions to discrete structures inside of the cell, called organelles (such as the nucleus), and, at the level of multi-cellular organisms, to ensure proper separation of different cell types (e.g. those found in different tissues and organs) while ensuring efficient communication between them. In fact, the human body is highly compartmentalized, from the cell level where local signals are generated and propagated in a highly ordered manner, to the whole body level. This book aims to introduce the interested reader to the universe of these complex segregated compartments in mammals. It discusses how the integrity of different types of barriers - endothelial, epithelial - is normally maintained and what could go wrong when these barriers' permeability becomes abnormally low or high in different disease states. We will focus on several such barriers, which are well studied and which are pivotal for a healthy well-being. In particular, we will focus on the skin, airways, the gut barrier, the endometrium, and cardiovascular and urinary systems. Special reference throughout the book will be made to several most novel groups of potential molecular candidates for the correction of barrier-related dysfunctions, in particular Transient Receptor Potential channels. Hence the title of the book has a triple meaning - a trip in its common sense, TRP channels (as in TRiP database) and Translating Research Into Practice (TRIP). Our team of authors is comprised of physiologists, pharmacologists, biophysicists and medics, including the national representative of Ukraine in the European Crohn's and Colitis organization (ECCO) and a member of the Scientific Committee of the European Association of Urologists. We include clinical cases and discuss molecular and cellular mechanisms underlying such real-life problems in-depth"-- Provided by publisher Bibliography Includes bibliographical references and index Notes Description based on print version record and CIP data provided by publisher; resource not viewed Subject Epithelial cells. Diseases. Molecular microbiology. Diseases Epithelial cells Molecular microbiology Form Electronic book Author Zholos, Alexander V., editor Tolstanova, Ganna M., editor LC no. 2021044656 ISBN 1685071392 9781685071394

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