| Description |
1 online resource (ix, 163 pages) : illustrations |
| Contents |
Intro -- Preface -- Contents -- Chapter 1: Discovery of a New Dendritic Cell Subset -- 1.1 A Brief Biosketch of the Immune System -- 1.2 Discovery of the Conventional Dendritic Cells -- 1.3 The Search for a Professional Interferon Producer -- 1.4 A New Dendritic Cell Subset Is the ̀̀Professional Interferon Producer ́́ -- 1.5 Conclusion -- References -- Chapter 2: Origin and Transcriptional Identity of Plasmacytoid Dendritic Cells -- 2.1 FLT3-Receptor Dependence and Shared Origin of cDCs and pDCs -- 2.2 Myeloid Versus Lymphoid Origin of pDCs |
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2.3 Transcriptional Program for pDC Commitment and Function -- 2.3.1 E2-2 -- 2.3.2 IRF8 -- 2.3.3 Regulators of Functional Identity -- 2.4 Localization and Migration of pDCs -- 2.5 Conclusions -- References -- Chapter 3: Activation and Functions of Plasmacytoid Dendritic Cells -- 3.1 Toll-like Receptor Activation and Signaling in pDCs -- 3.2 Cell Biology of Endosomal TLR Localization in pDCs -- 3.3 The Cytokine Response in pDCs in Response to TLR Activation -- 3.4 Antigen Presentation by pDCs -- 3.5 Cell Biology of Differential pDC Response to TLR Activation |
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3.6 Cellular Metabolism of Activated pDCs -- 3.7 The Elusive Role of IL-3 in pDC Immunobiology -- 3.8 Functional Heterogeneity of Plasmacytoid Dendritic Cells -- 3.9 Regulators of Type I IFN Induction by pDCs -- 3.9.1 ILT7 -- 3.9.2 BDCA2 -- 3.9.3 Siglec-H -- 3.10 Other Regulatory Surface Molecules in pDCs -- 3.11 Endocannabinoids and Cannabinoid Receptors -- 3.12 Metabolite Transporters and Receptors -- 3.13 Effect of Biological Sex on pDC Activation -- 3.14 Conclusions -- References -- Chapter 4: Plasmacytoid Dendritic Cells and Infections -- 4.1 RNA Viruses and pDCs |
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4.2 Human Immunodeficiency Virus and pDCs -- 4.3 PDCs and the Novel Coronavirus SARS-CoV-2 -- 4.4 DNA Viruses and pDCs -- 4.5 PDCs in Bacterial Infections -- 4.5.1 Extracellular Bacteria and pDCs -- 4.5.2 Intracellular Bacteria and pDCs -- 4.6 PDCs in Malaria -- 4.7 PDCs in Fungal Infections -- 4.8 Conclusions -- References -- Chapter 5: Plasmacytoid Dendritic Cells in Autoimmunity -- 5.1 Systemic Lupus Erythematosus -- 5.2 Psoriasis -- 5.3 Systemic Sclerosis -- 5.4 Sjogrenś Syndrome -- 5.5 Role of pDCs in Other Major Rheumatological Disorders -- 5.6 Conclusions -- References |
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Chapter 6: Plasmacytoid Dendritic Cells and Metabolic Disorders -- 6.1 Type 1 Diabetes Mellitus -- 6.2 Obesity and Type 2 Diabetes -- 6.3 Cardiovascular Components of Metabolic Syndrome -- 6.4 Fatty Liver Disease and Hepatic Metaflammation -- 6.5 A Potential Pathogenic Continuum for Autoimmune Diseases and Metabolic Syndrome -- 6.6 Conclusions -- References -- Chapter 7: Tolerogenic Functions of Plasmacytoid Dendritic Cells -- 7.1 Thymic pDCs and Central Tolerance -- 7.2 Mucosal Tolerance Driven by pDCs -- 7.3 Tolerogenic pDCs and Tissue Transplantation -- 7.4 Suppression of Anti-cancer Immunity |
| Summary |
This book provides a systemic review of the development, function, and role of plasmacytoid Dendritic Cells (pDCs) in human diseases. The chapters of the book discuss the origin and discovery, heterogeneity, development, and transcriptional regulation of pDCs. It also discusses the role of pDCs in human diseases, including cancers, metabolic disorders, and autoimmune/inflammatory diseases, and opportunities for pDCtargeting therapies in these diseases. It also highlights the current understanding of pDC involvement in autoimmunity and alloreactivity and opportunities for pDCtargeting therapies in the disorders. Lastly, it reviews the experimental methodologies and animal models that are used to explore the functions of pDCs |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 3, 2022) |
| Subject |
Dendritic cells.
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Immunology.
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Dendritic cells
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Immunology
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| Form |
Electronic book
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| ISBN |
9789811955952 |
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9811955956 |
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