| Description |
1 online resource |
| Contents |
Front Cover; Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine; Copyright; Contents; Contributors; Preface; Introduction: Human Genome Projects: The Omics Starting Point; Preomics Era; Omics Era; Omics in the Assisted Reproduction Era; Genomics; Prenatal; Transcriptomics; Proteomics and Metabolomics; References; Chapter 1: Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going?; Introduction; Specific Aspects of Basic Semen Analysis; Semen Volume; Estimation of Sperm Concentration; Sperm Motility |
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The Biological Relevance of Sperm MotilitySperm Morphology Analysis; Plasma Membrane Integrity; Conclusions; References; Chapter 2: Genetic Variations and Male Infertility; Introduction; Single Nucleotide Polymorphisms; MTHFR Gene Polymorphisms; DAZL and DAZ Genes Polymorphisms; BRDT Gene Polymorphisms; TERT and TEP1 Genes; Cytochrome P4501A1; FSHR Gene Polymorphisms; ESR1 and ESR2 Gene Polymorphisms; PRM1 and PRM2 Genes Polymorphisms; Insertion Deletion Polymorphisms; POLG Gene Polymorphisms; AR Gene Polymorphisms; Copy Number Variations; Y Chromosome Microdeletions |
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Genome-Wide Association StudiesLimitations of Genetic Association Studies; Conclusion; References; Further Reading; Chapter 3: New Genetic Point Mutations in Male Infertility; Introduction; Genes and Male Factor Infertility; Male Sexual Differentiation Disorders and Gonadal Development Impairment; Spermatogenesis Alterations and Sperm Function Impairment; Single-Nucleotide Polymorphism; Final Comments; References; Chapter 4: Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices; Introduction to Genetics; Genetic Disease and Inheritance |
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Introduction to Carrier ScreeningGuidelines for Carrier Screening; Carrier Screening Technologies; CBC and Hemoglobin Electrophoresis; HEXA (Tay-Sachs) Enzyme Analysis; Fragile X Syndrome-CGG and AGG Analysis; Spinal Muscular Atrophy (SMA) Dosage Analysis; Carrier Rates, Detection Rates, and Residual Risks; Reproductive Options for High-Risk Couples; Further Reading; Chapter 5: Telomeres in Germ Line and Early Embryo: An Overview; Historical Landmarks; Structure of Telomeres; Telomere Physiology; Telomeres in Aging and Age-Related Disease; Telomeres in Male Germ Line |
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Telomeres in Female Germ LineTelomeres in Early Embryo; Concluding Considerations; Acknowledgments; References; Chapter 6: Human Protamine Genes' Polymorphisms as a Possible Cause Underlying Male Infertility; Introduction; Protamine Structure and Functions; Protamine Genes Organization; PRM1/PRM2 Ratio; Protamine 1 Gene Polymorphisms; Polymorphisms in the Promoter Region; Polymorphisms in the Coding Region; Polymorphisms in the 3′ Noncodifying Region; Protamine 2 Gene Polymorphisms; Polymorphisms in the Promoter Region; Polymorphisms in the Coding Region |
| Summary |
Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime GosïŽlvez and JosïŽ A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (Ebsco, viewed July 17, 2018) |
| Subject |
Human reproduction.
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Genomics.
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Reproductive technology.
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Human beings.
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Humans
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Infertility -- genetics
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Genomics
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Infertility -- therapy
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Reproductive Techniques
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Reproduction
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Homo sapiens (species)
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Reproductive technology
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Genomics
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Human reproduction
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| Form |
Electronic book
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| Author |
Gosálvez, Jaime, author
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| ISBN |
9780128126769 |
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0128126760 |
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