| Description |
1 online resource |
| Contents |
Cardiovascular alterations -- Cancer -- Other pathological processes -- Conclusions -- Abbreviations used in this chapter -- References -- Chapter 5 Proteolytic processing in autophagy -- Autophagy in health and disease -- Inducing-autophagy proteases -- Cysteine cathepsin inhibitors and the autophagic process -- Inhibiting-autophagy proteases -- Conclusion remarks and perspectives -- References -- Chapter 6 Proteases are cut out to regulate acute and chronic inflammation -- Introduction to inflammation -- Cytokines -- Chemokines -- The roles of proteases in sepsis -- The roles of proteases in Crohn's disease -- Conclusions -- References -- Chapter 7 Proteolytic processing of laminin and the role of cryptides in tumoral biology -- Laminin -- Laminin-111 cryptides -- YIGSR (YIGSR, short arm of beta1 chain) -- IKVAV (IKVAV, long arm of alpha1 chain) -- AG73 (RKRLQVQLSIRT, LG4 domain of alpha1 chain) -- C16 (KAFDITYVRLKF, gamma1 chain) -- Conclusion -- References -- Chapter 8 Proteolytic signaling in cutaneous wound healing -- Introduction -- Wound healing phases -- Phase I: Hemostasis -- Phase II: Inflammation -- Phase III: Proliferation -- Phase IV: Remodeling -- Wound healing disruption and chronicity -- Proteases -- Serine proteases -- Coagulation cascade -- Anticoagulant signaling and fibrinolysis -- Neutrophil proteases, tissue kallikreins, and complement system -- Metalloproteases -- Matrixins -- Adamalysins and astacins -- Cysteine proteases -- Cathepsins -- Exogenous proteases -- Conclusion -- References -- Chapter 9 Proteinase imbalance in oral cancer and other diseases -- Proteolysis in oral cancer -- Overview on proteolysis -- Proteinases and inhibitors in oral cancer -- Saliva peptidomics in oral cancer -- Zinc metalloproteinases: A family of proteinases involved in the balance between health and disease -- Adam17 -- ADAM17 history |
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ADAM17 structure and biological function -- ADAM17 in development, inflammation, and cancer -- ADAM17: A potential therapeutic biomarker -- ADAM17: Employing different tools to study the mechanism of regulation in health and disease -- ADAM17 catalytic site-dependent regulation -- ADAM17 regulation at the substrate level -- ADAM17 regulation by novel uncovered substrates in OSCC -- ADAM17 regulation at the maturation level -- ADAM17 role as a potential therapeutic target -- ADAM17 noncatalytic site-dependent regulation -- ADAM17 regulation by inside-outside cross talk promoted by the cytoplasmic domain -- Direct and indirect effect of thiol-isomerase on ADAM17 activity -- ADAM17 effect on thiol isomerase activity and protein dimeric conformation -- Perspectives and conclusions -- Acknowledgments -- References -- Chapter 10 "Omics" approaches to determine protease degradomes in complex biological matrices -- Introduction -- Experimental design for protease degradome profiling -- Substrate discovery with recombinant proteases in vitro -- Modulation of protease abundance in cell culture -- Modulation of protease activity in vivo -- Quantitative bottom-up proteomics -- Data-dependent acquisition of peptide fragment spectra -- Improved quantification by targeted mass spectrometry -- Data-independent acquisition of peptide fragment spectra -- Protease substrate discovery by quantitative shotgun proteomics -- Selective enrichment and proteome-wide characterization of protein termini -- Enrichment of protein N-termini -- Enrichment of protein C-termini -- Positional proteomics data analysis -- Peptidomics -- Conclusions -- Acknowledgments -- References -- Chapter 11 The protease web -- Introduction -- Classification systems of proteases -- Regulation of protease activity by proteases -- Regulation of protease activity by protease inhibitor proteins |
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Conceptualization of the protease web -- Network biology and the protease web -- Introduction to network biology -- Network models of the protease web reveal structural properties -- Prediction of novel proteolytic pathways in the protease web -- Data and databases of protease interactions -- Identification of protease interactions -- Outlook -- Acknowledgment -- References -- Chapter 12 The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases -- Introduction -- Overview of snakebite envenomation -- Snakebite envenomation epidemiology -- Brief overview of medically relevant venomous snakes -- Clinical manifestations of snakebites: Envenomation symptoms -- Snake venom metalloproteinases related to hemorrhagic effects -- Tissue effects and mechanisms evolving SVMP in hemorrhage -- Cell effects and signaling events that might be evolved in the hemorrhage induced by SVMPs -- Non-catalytic domains involved in SVMPs effects: DC domain -- Therapeutic strategies targeting hemostatic disturbance of snake venoms: Antivenoms and new therapies -- Molecules from natural products as alternative therapy methods for snake envenoming local effects -- Small molecule inhibitors as alternative therapy methods -- Conclusions remarks -- References -- Index |
| Summary |
"Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field"-- Provided by publisher |
| Notes |
Print version record |
| Subject |
Proteolytic enzymes.
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Proteolytic enzymes
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| Form |
Electronic book
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| Author |
Zelanis, André, editor
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| ISBN |
9780323856973 |
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0323856977 |
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