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Book Cover
E-book

Title Advances in metallodrugs preparation and applications in medicinal chemistry / edited by Shahid-ul-Islam, Athar Adil Hashmi, Salman Ahmad Khan
Edition First edition
Published Hoboken, NJ : Wiley-Scrivener, 2020

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Description 1 online resource
Contents Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Chapter 1 Metallodrugs in Medicine: Present, Past, and Future Prospects -- 1.1 Introduction -- 1.2 Therapeutic Metallodrugs -- 1.2.1 Anticancer Metallodrugs -- 1.2.1.1 Mechanism of Anticancer Action -- 1.2.2 Antimicrobial and Antiviral Metallodrugs -- 1.2.2.1 Antimicrobial Metallodrugs -- 1.2.2.2 Antiviral Metallodrugs -- 1.2.3 Radiopharmaceuticals and Radiodiagnostic Metallodrugs -- 1.2.4 Anti-Diabetic Metallodrugs -- 1.2.5 Catalytic Metallodrugs -- 1.3 Future Prospects -- 1.4 Conclusion -- References
Chapter 2 Chemotherapeutic Potential of Ruthenium Metal Complexes Incorporating Schiff Bases -- 2.1 Introduction -- 2.2 Schiff Base Complexes of Ruthenium as Anticancer Agents -- 2.3 Conclusion -- References -- Chapter 3 Role of Metallodrugs in Medicinal Inorganic Chemistry -- 3.1 Introduction -- 3.2 Platinum Anticancer Drugs -- 3.2.1 Nucleophilic Displacement Reactions in Complexes of Platinum -- 3.2.2 Mode of the Interaction of Cisplatin Species With Nitrogen Donors of DNA Strand -- 3.2.3 Systemic Toxicity of Cisplatin -- 3.3 Copper-Based Anticancer Complexes
3.3.1 Copper is Essential for Health and Nutrition -- 3.3.2 Healthcare Applications of Copper -- 3.3.3 Copper and Human Health Disorders -- 3.3.3.1 Wilson's Disease (WD) -- 3.3.3.2 Menkes' Disease -- 3.3.4 Role of Copper Complexes as Potential Therapeutic Agents -- 3.3.4.1 Thiosemicarbazones-Based Complexes -- 3.3.4.2 Quinolones-Based Copper Complexes -- 3.3.4.3 Naphthoquinones -- 3.4 Zinc Anticancer Complexes -- 3.4.1 Biologically Importance of Zinc -- 3.4.2 Schiff Base Chemistry -- 3.4.2.1 Schiff Base and Their Metal Complexes -- 3.4.3 Zinc-Based Complexes -- 3.4.4 Top Food Sources of Zinc
3.4.5 Role of Zinc in Human Body -- 3.4.6 Zinc as a Health Benefit -- 3.4.7 Zinc in Alloy and Composites -- 3.4.8 Zinc Supplementation as a Treatment -- 3.4.8.1 Zinc Deficiency -- 3.4.8.2 Zinc Toxicity -- 3.4.8.3 Zinc and Viral Infections -- 3.4.9 Gastrointestinal Effects -- 3.5 Future Prospects of Metallodrugs -- References -- Chapter 4 Ferrocene-Based Metallodrugs -- 4.1 Introduction -- 4.2 Ferrocene-Based Antimalarial Agents -- 4.2.1 Mechanism of Action -- 4.3 Ferrocene-Based Antibacterial and Antifungal Drugs -- 4.3.1 Schiff Base Derived Ferrocene Conjugates as Antibacterial Agents
4.3.2 Ferrocenyl Guanidines as Antibacterial and Antifungal Agents -- 4.3.3 Sedaxicene as Antifungal Agents -- 4.4 Ferrocene-Based Anti-Tumor and Anti-Cancerous Drugs -- 4.4.1 Ferricenium Salts as Anti-Tumor Agents -- 4.4.2 Ferrocenylalkylazoles Active Anti-Tumor Drugs -- 4.4.3 Ferrocene Conjugated to Peptides for Lung Cancer -- 4.4.4 Ferrocenylalkyl Nucleobases Potential Anti-Cancerous Drugs -- 4.4.5 Ferrocenyl Sub-Ordinates of Illudin-M -- 4.4.6 Ferrocenyl Derivatives of Retinoids Potential Anti-Tumor Drug
Summary "Over the past few decades, medicinal inorganic chemistry as an interdisciplinary sub-area of bioinorganic chemistry has received the growing attention of researchers in the search for promising antimicrobial, antimalarial, antiviral, and antitumor chemotherapeutic agents. An excellent compilation of reports on metal complexes has revealed the potency of metal complexes as better therapeutic agents. Metal-containing drugs have several promising advantages over organic ligands and have gained the trust of researches after the worldwide approval of the drug cisplatin. Their distinct mechanism of action makes them perfect candidates as alternatives to the conventional drugs to which resistance has already been shown. In this direction, a huge number of transition metal complexes have been synthesized and evaluated for their biological profiles"-- Provided by publisher
Subject Metals -- Therapeutic use.
Metals -- Therapeutic use
Form Electronic book
Author Ul-Islam, Shahid editor
Hashmi, Athar Adil, editor
Khan, Salman Ahmad, editor
LC no. 2020020785
ISBN 9781119641018
1119641012