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Title Retinal degenerations : biology, diagnostics, and therapeutics / edited by Joyce Tombran-Tink and Colin J. Barnstable
Published Totowa, N.J. : Humana Press, ©2007

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Description 1 online resource (xvii, 466 pages) : illustrations
Series Ophthalmology research
Ophthalmology research.
Contents Coping with retinal degeneration : a patient's view / Gordon Cousins and James Cape -- Epidemiology of age-related macular degeneration early in the 21st century / Jie Jin Wang, Paul Mitchell, and Ronald Klein -- Leber congenital amaurosis : a hereditary childhood form of blindness and a model to elucidate retinal physiology and development / Robert K. Koenekoop -- Macular degeneration : aging changes and novel therapies / Peter E. Liggett and Alejandro J. Lavaque -- Stargardt disease : from gene discovery to therapy / Rando Allikmets -- X-linked juvenile retinoschisis / Bernhard H.F. Weber and Ulrich Kellner -- Retinal degeneration in Usher syndrome / David S. Williams -- Mouse models of retinitis pigmentosa / Bo Chang [and others] -- The impact of diabetes on neuronal, glial, and vascular cells of the retina : implications for the pathogenesis of diabetic retinopathy / Sylvia B. Smith -- Statins and age-related maculopathy / Gerald McGwin, Jr. and Cynthia Owsley -- The role of drusen in macular degeneration and new methods of quantification / R. Theodore Smith and Umer F. Ahmad -- RPE lipofuscin : formation, properites, and relevance to retinal degeneration / Janet R. Sparrow -- Genetic modifiers that affect phenotypic expression of retinal diseases / Malia M. Edwards [and others] -- X-linked retinal dystrophies and microtubular functions within the retina / Alan F. Wright and Xinhua Shu -- Synaptic remodeling in retinal degeneration / You-Wei Peng and Fulton Wong
On the suppression of photoreceptor cell death in retinitis pigmentosa / Fiona Kernan [and others] -- Cell-based therapies to restrict the progress of photoreceptor degeneration / Raymond D. Lund and Shaomei Wang -- Current status of IPE transplantation and its potential as a cell-based therapy for age-related macular degeneration and retinal dystrophies / Makoto Tamai -- Recent results in retinal transplantation give hope for restoring vision / Robert B. Aramant, Norman D. Radtke, and Magdalene J. Seiler -- Stem cells and retinal transplantation / Joanne Yau [and others] -- Application of encapsulated cell technology for retinal degenerative diseases / Weng Tao and Rong Wen -- Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leber's congenital amaurosis / Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger -- The use of neuroprotective factors in retinal degenerations / Joyce Tombran-Tink and Colin J. Barnstable -- Carbonic anhydrase inhibitors as a possible therapy for RP17, an autosomal dominant retinitis pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response / George Rebello, Jacquie Greenberg, and Raj Ramesar -- Macular Degeneration- an addendum / Joyce Tombran-Tink and Colin J. Barnstable
Summary For centuries, humans have tried to explain the complex process of vision and find effective treatments for eye diseases. Perhaps the oldest surviving record of ancient ophthalmic practices is the Babylonian code of Hammurabi that over 4000 years ago, mentioned fees for eye surgery--and penalties for unsuccessful operations that led to loss of the eye. Babylonian medicine was controlled by priests who directed the work of skilled surgeons. The earliest records of Egyptian medicine date from almost the same time. The Ebers Papyrus, dating back to more than 3500 years ago is a superbly preserved document in which a section outlines a relatively advanced system of diagnosis and treatment of various ocular pathologies. The text reveals that ancient Greek and Egyptian physicians prescribed "liver juice" for night blindness. This was obtained from roasted and crushed ox liver. We now know that their prescription contained a remarkable amount of vitamin A. It was only within the last century, however, that we have recognized the importance of vitamin A to the function of photoreceptors and visual acuity and that its deficiency can result in night blindness. Egyptian ophthalmological practices were held in high esteem in the ancient world and so were their medical institutes, called "peri-ankh," which existed since the first dynasty. Herodotus, the fifth century BC Greek historian, comments on the specialization of the physicians: "Each physician treats just one disease
Bibliography Includes bibliographical references and index
In Springer e-books
Subject Retinal degeneration.
Retinal Degeneration
MEDICAL -- Ophthalmology.
HEALTH & FITNESS -- Vision.
Retinal degeneration
Form Electronic book
Author Tombran-Tink, Joyce.
Barnstable, Colin J.
ISBN 1588296202
9781588296207
9781597451864
159745186X