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Book Cover
Book
Author Patrick, Graham L., author

Title An introduction to medicinal chemistry / Graham Patrick
Edition Sixth edition
Published Oxford : Oxford University Press, 2017

Copies

Location Call no. Vol. Availability
 MELB  615.19 Pat/Ait 2017  AVAILABLE
 MELB  615.19 Pat/Ait 2017  AVAILABLE
 W'PONDS  615.19 Pat/Ait 2017  AVAILABLE
 W'PONDS  615.19 Pat/Ait 2017  AVAILABLE
Description xxxi, 877 pages : illustrations (black and white, and colour) ; 27 cm
Contents Drugs and drug targets : an overview. Drug targets. Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Pharmacodynamics and pharmacokinetics. Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery, design, and development. Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Tools of the trade. Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Selected topics in medicinal chemistry. Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opioid analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions
Notes Previous edition: 2013
Bibliography Includes bibliographical references and index
Subject Pharmaceutical chemistry.
Drug Design.
Pharmacokinetics.
Chemistry, Pharmaceutical.
Drugs -- Design.
ISBN 9780198749691
0198749694