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Book Cover
Author Thiriet, Marc.

Title Intracellular signaling mediators in the circulatory and ventilatory systems / Marc Thiriet
Published New York, NY : Springer, [2013]
Online access available from:
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Description 1 online resource
Series Biomathematical and biomechanical modeling of the circulatory and ventilatory systems, 2193-1682 ; v. 4
Biomathematical and biomechanical modeling of the circulatory and ventilatory systems ; v. 4
Contents Signaling lipids -- Preamble to cytoplasmic protein kinases -- Cytoplasmic protein tyrosine kinases -- Cytoplasmic protein serine/Threonine kinases -- Mitogen-Activated protein kinase module -- Dual-Specificity protein kinases -- Cytosolic protein phosphatases -- Guanosine triphosphatases and their regulators -- Other major types of signaling mediators -- Signaling pathways -- Conclusion
Summary The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
Analysis Cardiology
Biological models
Biomedical engineering
Biophysics and Biological Physics
Mathematical and Computational Biology
Systems Biology
Bibliography Includes bibliographical references and index
Subject Cellular signal transduction.
Biological models.
Cardiovascular Physiological Phenomena.
Cell Communication.
Models, Theoretical.
Respiratory Physiological Phenomena.
Form Electronic book
LC no. 2012941609
ISBN 9781461443704 (electronic bk.)
1461443709 (electronic bk.)