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Book Cover
E-book
Author Schiessel, Helmut.

Title Biophysics for Beginners A Journey Through the Cell Nucleus
Edition 2nd ed
Published Milton : Jenny Stanford Publishing, 2021

Copies

Description 1 online resource (528 p.)
Contents Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface to the First Edition -- Preface to the Second Edition -- Chapter 1: Molecular Biology of the Cell -- 1.1: The Central Dogma of Molecular Biology -- 1.2: A Journey through the Cell Nucleus -- Chapter 2: Statistical Physics -- 2.1: The Partition Function -- 2.2: Applications -- 2.3: The Entropy -- 2.4: Particles with Interactions and Phase Transitions -- 2.5: Biomolecular Condensates -- Chapter 3: Polymer Physics -- 3.1: Random Walks -- 3.2: Freely Jointed and Freely Rotating Chains
3.3: The Role of Solvent Quality -- 3.4: Self-Avoiding Walks -- 3.5: The Flory Argument -- 3.6: The Blob Picture -- 3.7: Polymers in Poor Solvents -- 3.8: Internal Structure of Polymers -- Chapter 4: DNA -- 4.1: The Discovery of the DNA Double Helix -- 4.2: DNA on the Base Pair Level -- 4.2.1: A Geometrical Approach -- 4.2.2: A Statistical Physics Approach -- 4.3: DNA as a Wormlike Chain -- 4.4: DNA Melting -- Chapter 5: Stochastic Processes -- 5.1: Introduction -- 5.2: Markov Processes -- 5.3: Master Equation -- 5.4: Fokker-Planck Equation -- 5.5: Application: Escape over a Barrier
5.6: Application: Dynamic Force Spectroscopy -- 5.7: Langevin Equation -- 5.8: Application: Polymer Dynamics -- Chapter 6: RNA and Protein Folding -- 6.1: RNA Folding -- 6.2: Protein Folding -- Chapter 7: Electrostatics inside the Cell -- 7.1: Poisson-Boltzmann Theory -- 7.2: Electrostatics of Charged Surfaces -- 7.3: Electrostatics of Cylinders and Spheres -- 7.4: Debye-Hückel Theory -- 7.5: Breakdown of Mean Field Theory -- Chapter 8: DNA-Protein Complexes -- 8.1: Protein Target Search -- 8.2: RNA Polymerase -- 8.3: Nucleosome Dynamics -- 8.3.1: Site Exposure Mechanism
8.3.2: Force-Induced Nucleosome Unwrapping -- 8.3.3: Nucleosome Sliding -- 8.4: Chromatin Fibers -- 8.4.1: Two-Angle Model -- 8.4.2: Solenoid-Type Models -- 8.5: Chromatin at Large Scales -- 8.5.1: From Classical Polymers to Fractal Globules -- 8.5.2: From Polymer Rings to Loop Extrusion -- Chapter 9: Computational Methods -- 9.1: Molecular Dynamics Simulations -- 9.2: Monte Carlo Simulations -- Appendix A: Probability Theory -- Appendix B: The Distribution of Magnetization and the Central Limit Theorem -- Appendix C: Connection between Polymer Statistics and Critical Phenomena
Appendix D: Hamilton's Principle and the Pendulum -- Appendix E: Fourier Series -- Appendix F: The Pre-Averaging Approximation -- Appendix G: Interaction between Two Equally Charged Plates at Zero Temperature -- Appendix H: Geometries of Chromatin Fiber Models -- References -- Index
Summary Biophysics is a new way of looking at living matter. It uses quantitative experimental, theoretical, and computational methods, thereby opening a new window for studying and understanding life processes. This textbook provides a brief introduction to the basics of the field, followed by in-depth discussions of more advanced biophysics subjects, going all the way to state-of-the-art experiments and their theoretical interpretations. The second edition presents some of the newest developments in the field (e.g., biomolecular condensates, loop extrusion), a new chapter on computational methods, and many computer exercises specially designed for this textbook
Notes Description based upon print version of record
Helmut Schiessel studied physics at the Albert-Ludwigs University, Freiburg, Germany. There he earned his PhD under the guidance of Prof. A. Blumen in the Group for Theoretical Polymer Physics. After graduating in 1997, he worked as a postdoc with Prof. P. A. Pincus at the University of California, Santa Barbara. Then, he was a joint postdoc with Profs. W. M. Gelbart and R. Bruinsma at the University of California, Los Angeles. In 2000, he joined the Theory Group of the Max Planck Institute for Polymer Research, Mainz, Germany, where he was in charge of a biophysics research project. From 2005 to 2020, Prof. Schiessel headed the chair of Theoretical Physics of LifeProcesses in the Instituut-Lorentz at Leiden University, the Netherlands. In 2021, he joined the Cluster ofExcellence Physics of Life at the Technical University in Dresden, Germany, where he heads the TheoreticalPhysics of Living Matter Group
Subject Biophysics.
Cell nuclei.
DNA.
RNA.
SCIENCE / Life Sciences / Biophysics
Biophysics
Cell nuclei
DNA
RNA
Form Electronic book
ISBN 9781000468632
1000468631
9781003223108
1003223109
9781000468625
1000468623