Title Looking at Ribozymes : Biology of Catalytic RNA

Edition 1st ed Published Newark : John Wiley & Sons, Incorporated, 2024 ©2024

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Description 1 online resource (188 pages) Contents Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Preface -- Chapter 1. Fundamentals of RNA and Ribozyme Structure -- 1.1. Sequences and secondary structures -- 1.2. RNA folding, tertiary structures and 3D -- 1.2.1. Secondary structures and RNA folding -- 1.2.2. The pseudoknot -- 1.2.3. The loop E -- 1.2.4. The k-turn -- 1.2.5. Tetra-loop receptors -- 1.2.6. The A-minor pattern -- 1.2.7. Comparative analysis of sequences -- Chapter 2. Ribozymes and the "Central Dogma" of Molecular Biology -- 2.1. The discovery of RNA catalysis and the central dogma of molecular biology -- 2.2. In search of the primordial polymerase -- Chapter 3. The Discovery of Ribozymes -- 3.1. The discovery of catalysis by autocatalytic introns -- 3.2. The discovery of RNA catalysis of RNase P -- 3.3. The first consequences of these discoveries -- 3.3.1. The ribosome, a long-ignored ribozyme -- 3.3.2. The modified bases -- 3.4. The spliceosome, another ribozyme -- 3.4.1. Nucleolytic ribozymes -- Chapter 4. Ribozyme Engineering and the RNA World -- 4.1. Classification of ribozymes -- 4.2. Classification of ribozymes according to catalytic mechanism -- Chapter 5. Structures of Ribozymes -- 5.1. Structures and catalytic mechanisms of ribozymes -- 5.1.1. Hammerhead ribozymes -- 5.1.2. The example of the hairpin ribozyme -- 5.1.3. The example of the glmS ribozyme -- 5.2. An example of catalysis control: lariat-capping ribozyme -- Chapter 6. Evolution of the Vision of the Catalytic Mechanisms of Ribozymes, the Hammerhead Ribozyme -- 6.1. Chemistry and catalysis: between general acid/base and metal cations -- 6.2. Difficulties in interpreting catalysis data -- Chapter 7. The Distribution of Ribozymes in Living Organisms and Molecular Adaptations during Evolution -- 7.1. Ubiquitous ribozymes -- 7.2. Selection pressures at work in ribozyme shaping 7.3. Ribozymes in cellular processes: from viroids to eukaryotes -- 7.4. Very human ribozymes -- Conclusion -- References -- Index -- EULA Notes Description based on publisher supplied metadata and other sources Genre/Form Electronic books Form Electronic book Author Leclerc, Fabrice ISBN 1394276613 9781394276615

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