Title Pharmaceutical formulation development of peptides and proteins / edited by Lars Hovgaard, Sven Frokjaer, Marco van de Weert

Edition 2nd ed Published Boca Raton, Fla. : CRC Press, 2013

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Description 1 online resource (xii, 376 pages, 4 unnumbered pages of plates) : illustrations (some color) Contents Ch. 1. Peptide synthesis / Knud J. Jensen -- ch. 2. Protein expression / Nanni Din -- ch. 3. Protein purification / Lars Hovgaard, Lars Skriver, and Sven Frokjaer -- ch. 4. Characterization of therapeutic peptides and proteins / Marco van de Weert and Tudor Arvinte -- ch. 5. Chemical pathways of peptide and protein degradation / Teruna J. Siahaan and Christian Schöneich -- ch. 6. Physical instability of peptides and proteins / Marco van de Weert and Theodore W. Randolph -- ch. 7. Peptide and protein derivatives / Kristian Strømgaard and Thomas Høeg-Jensen -- ch. 8. Peptides and proteins as parenteral solutions / Michael J. Akers and Michael R. Defelippis -- ch. 9. Peptides and proteins as parenteral suspensions : an overview of design, development, and manufacturing considerations / Michael R. Defelippis and Michael J. Akers -- ch. 10. Rational design of solid protein formulations / Bingquan (Stuart) Wang and Michael J. Pikal -- ch. 11. Peptide and protein drug delivery systems for nonparenteral routes of administration / Ulrik Lytt Rahbek, František Hubálek, and Simon Bjerregaard -- ch. 12. Immunogenicity of therapeutic proteins / Grzegorz Kijanka [and others] -- ch. 13. Biosimulation of peptides and proteins / Tue Søeborg [and others] -- ch. 14. Registration of peptides and proteins / Niamh Kinsella Summary The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses:The synthesis of peptides and the biotechnolog Bibliography Includes bibliographical references and index Subject Peptides -- Synthesis. Pharmaceutical chemistry. Proteins -- Synthesis. Peptide Biosynthesis Chemistry, Pharmaceutical -- methods Protein Biosynthesis Chemistry, Pharmaceutical Peptides -- Synthesis Pharmaceutical chemistry Proteins -- Synthesis Form Electronic book Author Hovgaard, Lars, 1962- Frøkjær, Sven, 1947- Weert, Marco van de, 1973- LC no. 2012030490 ISBN 9781439853894 1439853894 1439853886 9781439853887

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