| Description |
1 online resource (405 pages) |
| Contents |
Front Matter -- Estrogens, Progestins, Allopregnanolone and Neuroprotection. Interactions of Estradiol and Insulin-Like Growth Factor-I in Neuroprotection: Implications for Brain Aging and Neurodegeneration / Mar̕a-Angeles Ařvalo, Luis M Garcia-Segura, Įigo Azcoitia -- Structure₆Nongenomic Neuroprotection Relationship of Estrogens and Estrogen-Derived Compounds / James W Simpkins, Kun Don Yi, Evelyn Perez, Douglas Covey -- Progestins and Neuroprotection: Why the Choice of Progestin Matters / Meharvan Singh -- Endogenous and Synthetic Neurosteroids in the Treatment of Niemann₆Pick Type C Disease / Synthia H Mellon, Wenhui Gong, Marcus D Schonemann -- Glucocorticoids, Dehydroepiandrosterone, Neuroprotection and Neuropathy. Glucocorticoids, Developmental ₃Programming,₄ and the Risk of Affective Dysfunction / Bayanne Olabi, Jonathan Seckl -- Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists / Paul J Lucassen, Carlos P Fitzsimons, Erno Vreugdenhil, Pu Hu, Charlotte Oomen, Yanina Revsin, Marian Jo͡ls, Edo Ronald de Kloet -- Neuroactive Steroids and Peripheral Neuropathy / Roberto C Melcangi, Silvia Giatti, Marzia Pesaresi, Donatella Caruso, Marc J Tetel -- Neuroprotective and Neurogenic Properties of Dehydroepiandrosterone and its Synthetic Analogs / Ioannis Charalampopoulos, Iakovos Lazaridis, Achille Gravanis -- Neurosteroids and Pain / Christine Patte-Mensah, Laurence Meyer, V̌ronique Schaeffer, Cherkaouia Kibaly, Ayikoe G Mensah-Nyagan -- Polypeptide Hormones and Neuroprotection. The Insulin/IGF-1 System in Neurodegeneration and Neurovascular Disease / Przemyslaw (Mike) Sapieha, Lois Smith -- Leptin Neuroprotection in the Central Nervous System / Feng Zhang, Suping Wang, Armando P Signore, Zhongfang Weng, Jun Chen -- Somatostatin and Neuroprotection in Retina / Kyriaki Thermos -- Neurotrophic Effects of PACAP in the Cerebellar Cortex / Anthony Falluel-Morel, Hubert Vaudry, Hitoshi Komuro, Dariusz C Gorecki, Ludovic Galas, David Vaudry -- The Corticotropin-Releasing Hormone in Neuroprotection / Christian Behl, Angela Clement -- Neuroprotective and Neurogenic Effects of Erythropoietin / Helmar C Lehmann, Ahmet H̲ke -- Hormones and Neurogenesis. Thyroid Hormone Actions on Glioma Cells / Min Zhou, Harold K Kimelberg, Faith B Davis, Paul J Davis -- Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications / Lifei Liu, Roberta Diaz Brinton -- Gonadotropins and Progestogens: Obligatory Developmental Functions during Early Embryogenesis and their Role in Adult Neurogenesis, Neuroregeneration and Neurodegeneration / Craig S Atwood, Sivan Vadakkadath Meethal -- Human Neural Progenitor Cells: Mitotic and Neurogenic Effects of Growth Factors, Neurosteroids, and Excitatory Amino Acids / Masatoshi Suzuki, Jacalyn McHugh, Narisorn Kitiyanant -- Corticosterone, Dehydroepiandrosterone, and Neurogenesis in the Adult Hippocampus / Joe Herbert, Scarlet Bella Pinnock -- Index |
| Summary |
As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hor |
| Notes |
17 Gonadal Hormones, Neurosteroids, and Clinical Progestins as Neurogenic Regenerative Agents: Therapeutic Implications18 Gonadotropins and Progestogens: Obligatory Developmental Functions during Early Embryogenesis and their Role in Adult Neurogenesis, Neuroregeneration and Neurodegeneration; 19 Human Neural Progenitor Cells: Mitotic and Neurogenic Effects of Growth Factors, Neurosteroids, and Excitatory Amino Acids; 20 Corticosterone, Dehydroepiandrosterone, and Neurogenesis in the Adult Hippocampus; Index |
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Description based upon print version of record |
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Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis; Contents; List of Contributors; Part I Estrogens, Progestins, Allopregnanolone and Neuroprotection; 1 Interactions of Estradiol and Insulin-like Growth Factor-I in Neuroprotection: Implications for Brain Aging and Neurodegeneration; 2 Structure-Nongenomic Neuroprotection Relationship of Estrogens and Estrogen-Derived Compounds; 3 Progestins and Neuroprotection: Why the Choice of Progestin Matters; 4 Endogenous and Synthetic Neurosteroids in the Treatment of Niemann-Pick Type C Disease |
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Part II Glucocorticoids, Dehydroepiandrosterone, Neuroprotection and Neuropathy5 Glucocorticoids, Developmental ''Programming, '' and the Risk of Affective Dysfunction; 6 Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists; 7 Neuroactive Steroids and Peripheral Neuropathy; 8 Neuroprotective and Neurogenic Properties of Dehydroepiandrosterone and its Synthetic Analogs; 9 Neurosteroids and Pain Christine Patte-Mensah, Laurence Meyer, Véronique Schaeffer, Cherkaouia |
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Part III Polypeptide Hormones and Neuroprotection10 The Insulin/IGF-1 System in Neurodegeneration and Neurovascular Disease; 11 Leptin Neuroprotection in the Central Nervous System; 12 Somatostatin and Neuroprotection in Retina; 13 Neurotrophic Effects of PACAP in the Cerebellar Cortex; 14 The Corticotropin-Releasing Hormone in Neuroprotection; 15 Neuroprotective and Neurogenic Effects of Erythropoietin; Part IV Hormones and Neurogenesis; 16 Thyroid Hormone Actions on Glioma Cells |
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Also available in print |
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Mode of access: World Wide Web |
| Subject |
Natural history.
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Physiology.
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Science.
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| Form |
Electronic book
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| Author |
Mellon, Synthia H.
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Wiley InterScience (Online service)
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| ISBN |
3527633847 |
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3527633960 (electronic bk.) |
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9783527633845 |
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9783527633968 (electronic bk.) |
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