| Description |
1 online resource (521 p.) |
| Series |
Medicinal Chemistry Lessons from Nature Ser. ; v.1 |
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Medicinal Chemistry Lessons from Nature Ser
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| Contents |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- KEY FEATURES -- Preface -- List of Contributors -- Polyphenols and Flavonoids: Chemical, Pharmacological and Therapeutic Aspects -- Stefania Cesa1,*, Francesco Cairone1 and Celeste De Monte1 -- INTRODUCTION -- CHEMICAL STRUCTURES, CLASSIFICATION AND PROPERTIES OF FLAVONOIDS -- Classes of Flavonoids with the B Ring on C2 -- Classes of Flavonoids with the B Ring on C3 -- Classes of Flavonoids Where the B Ring is Connected to the C Ring Through the 4th Position -- Classes of Open-Chain Flavonoids |
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PHARMACOLOGICAL ASPECTS OF POLYPHENOLS AND FLAVONOIDS -- BIOAVAILABILITY AND METABOLISM OF FLAVONOIDS, TOXICOLOGICAL ACTIVITY AND SEMI-SYNTHETIC STRATEGIES -- ADME of Flavonoids -- Factors that Could Affect ADME of Flavonoids -- Toxicity of Flavonoids -- Strategies for a Better Investigation of Flavonoids Properties -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases -- Barbara De Filippis1,* and Marialuigia Fantacuzzi1 -- INTRODUCTION |
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MULTITARGET ANALOGUES OF RSV -- Hybrids of RSV -- Derivatives of RSV -- Schiff Base Derivatives of RSV -- CONCLUDING REMARKS -- ABBREVIATIONS: -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Biological Activities of Synthetic Derivatives of Xanthones: An Update (2016-2020) -- Cristina Scarpecci1 and Sara Consalvi1,* -- INTRODUCTION -- XANTHONE SYNTHETIC DERIVATIVES FOR CANCER THERAPY -- Caged Xanthones (CXs) -- Mangostin Analogs -- Carboxyxanthones -- Dihydroxyxanthones -- N-Xanthone Benzensulphonamides -- Dioxygenated Xanthones |
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Combretastatin Derivatives as Tubulin Inhibitors: A Fascinating Journey from Nature to Drug Discovery Strategies -- Alessandra Ammazzalorso1,* and Trond Vidar Hansen2 -- INTRODUCTION -- INSIGHTS ON MECHANISM OF ACTION OF COMBRETASTATINS -- Development of Combretastatin Prodrugs -- Fosbretabulin, Ombrabulin and Oxi4503 -- Combretastatin Prodrugs With Improved Drug Delivery Ability -- Bioreductive Prodrugs of Combretastatins -- Photoresponsive Hybrid Prodrugs of Combretastatins -- DEVELOPMENT OF COMBRETASTATIN DERIVATIVES -- Combretastatin Derivatives Obtained by Bridge Modifications |
| Summary |
Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relations |
| Notes |
Description based upon print version of record |
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Carbocyclic Derivatives |
| Form |
Electronic book
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| ISBN |
9789815079098 |
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9815079093 |
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